Document Detail

Diffuse diabetic macular oedema treated by intravitreal triamcinolone acetonide: a comparative, non-randomised study.
MedLine Citation:
PMID:  15722313     Owner:  NLM     Status:  MEDLINE    
AIM: To report on visual outcome of patients receiving an intravitreal injection of triamcinolone acetonide for treatment of diffuse diabetic macular oedema.
METHODS: Prospective, comparative, non-randomised clinical interventional study included 136 patients with diffuse diabetic macular oedema. Patients of the study group (97 eyes) received an intravitreal injection of 20-25 mg of triamcinolone acetonide and no other retinal treatment. Patients of the control group (69 eyes) received focal or panretinal laser treatment if indicated. Mean (standard deviation) follow up was 8.4 (SD 6.0) months (range 1.03-25.2 months).
RESULTS: Visual acuity (VA) increased significantly (p<0.001) in the study group with 66 (68%) eyes gaining in VA by at least two Snellen lines. In the control group, VA did not change significantly during the first 4 months of follow up, and decreased significantly (p<0.001) towards the end of the follow up. Difference in change of best VA was significant (p<0.001) between both groups. Correspondingly, the number of patients with VA improvement of two or more Snellen lines and visual loss of two or more Snellen lines, respectively, was significantly (p<0.001) higher and lower, respectively, in the study group.
CONCLUSIONS: Intravitreal triamcinolone acetonide can temporarily increase VA in some patients with diffuse diabetic macular oedema.
J B Jonas; I Akkoyun; I Kreissig; R F Degenring
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  89     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-05-09     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University of Heidelberg, Heidelberg, Germany.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage*,  therapeutic use
Chi-Square Distribution
Diabetes Mellitus / drug therapy*,  physiopathology,  surgery
Follow-Up Studies
Laser Therapy
Macular Degeneration / drug therapy*,  physiopathology,  surgery
Middle Aged
Prospective Studies
Statistics, Nonparametric
Triamcinolone Acetonide / administration & dosage*,  therapeutic use
Visual Acuity
Vitreous Body
Reg. No./Substance:
0/Anti-Inflammatory Agents; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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