| Diffuse cerebrospinal gliomatosis with extensive leptomeningeal spread. | |
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MedLine Citation:
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PMID: 10992815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of diffuse cerebrospinal gliomatosis with extensive leptomeningeal spread is presented. The patient, an 18-year-old girl, was admitted due to progressive weakness and paresthesia of both legs, following rapid neuropsychiatric deterioration. An initial magnetic resonance imaging (MRI) study of the T-spine showed diffuse high signal intensities from T9 to T12 spinal cords on a T2 sagittal image and diffuse cord bulging at T1WI. This suggested an inflammatory lesion such as tuberculosis or fungal meningoencephalitis. A limited autopsy was performed. A microscopic examination revealed multifocal GFAP-positive astrocytic proliferations that were low grade astrocytoma in the cerebral leptomeninges, parietal, occipital and temporal lobes and anaplastic astrocytoma in the spinal cord and spinal leptomeninges. The high proliferative indices of the spinal lesion and aneuploidy correspond to a diagnosis of malignant astrocytoma and a rapid fatal clinical course. |
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Authors:
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J Y Bae; B O Choi; I N SunWoo; D I Kim; S H Cho; T S Kim |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Yonsei medical journal Volume: 41 ISSN: 0513-5796 ISO Abbreviation: Yonsei Med. J. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-09-28 Completed Date: 2000-09-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0414003 Medline TA: Yonsei Med J Country: KOREA (SOUTH) |
Other Details:
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Languages: eng Pagination: 517-21 Citation Subset: IM |
Affiliation:
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Department of Pathology, Pochon CHA University College of Medicine, Pundang, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain / pathology Cell Division Diagnosis, Differential Female Humans Magnetic Resonance Imaging Meninges / pathology* Neoplasms, Neuroepithelial / diagnosis, pathology* Spinal Cord / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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