Document Detail

Diffuse bone marrow uptake on F-18 FDG PET in patients with myelodysplastic syndromes.
MedLine Citation:
PMID:  17053396     Owner:  NLM     Status:  MEDLINE    
It is well known that hematopoietic cytokine stimulation can cause diffuse increase of FDG accumulation in bone marrow on PET imaging, which simulates that seen in patients with bone marrow metastases. However, diffuse bone marrow FDG uptake can be caused by other etiologies. We report 2 patients who did not have a history of hematopoietic cytokine stimulation. The FDG PET images showed diffuse bone marrow FDG uptake, and the patients were diagnosed as having myelodysplastic syndromes. These cases demonstrate that diffuse FDG uptake by bone marrow can suggest neoplastic disease of the hematopoietic tissues.
Kentaro Inoue; Ken Okada; Hideo Harigae; Yasuyuki Taki; Ryoi Goto; Shigeo Kinomura; Shunsuke Kato; Tomohiro Kaneta; Hiroshi Fukuda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  31     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  721-3     Citation Subset:  IM    
Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
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MeSH Terms
Bone Marrow / metabolism*,  radionuclide imaging*
Bone Marrow Neoplasms / metabolism,  radionuclide imaging
Diagnosis, Differential
Fluorodeoxyglucose F18 / diagnostic use*,  pharmacokinetics*
Middle Aged
Myelodysplastic Syndromes / metabolism*,  radionuclide imaging*
Positron-Emission Tomography / methods*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Tissue Distribution
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

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