Document Detail

Diffuse axonal damage, myelin impairment, astrocytosis and inflammatory response following microinjections of NMDA into the rat striatum.
MedLine Citation:
PMID:  17899345     Owner:  NLM     Status:  MEDLINE    
White matter damage and inflammatory response are important secondary outcomes after acute neural disorders. Nevertheless, a few studies addressed the temporal outcomes of these pathological events using non-traumatic models of acute brain injury. In the present study, we describe acute inflammatory response and white matter neuropathology between 1 and 7 days after acute excitotoxic striatal damage. Twenty micrometer sections were stained by hematoxylin and eosin technique for gross histopathological analysis and immunolabed for neutrophils (anti-mbs-1), activated macrophages/microglia (anti-ed1), astrocytes (anti-gfap), damaged axons (anti-betaapp) and myelin basic protein (MBP). Recruitment peak of neutrophils and macrophages occurred at 1 and 7 days post-nmda injection, respectively. Diffuse damaged axons (beta-app + end-bulbs) were apparent at 7 days, concomitant with progressive myelin impairment and astrocytosis. Further studies using electron microscopy and blockers of inflammatory response and glutamatergic receptors should be performed to confirm and address the mechanisms of white matter damage following an excitotoxic lesion.
Rafael R Lima; Joanilson Guimaraes-Silva; Jorge L Oliveira; Ana Maria R Costa; Renata D Souza-Rodrigues; Claudia D Dos Santos; Cristovam W Picanço-Diniz; Walace Gomes-Leal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-25
Journal Detail:
Title:  Inflammation     Volume:  31     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-35     Citation Subset:  IM    
Laboratory of Experimental Neuroprotection and Neuroregeneration, Department of Morphology, Biological Sciences Center, Federal University of Pará, Belém-Pará, Brazil.
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MeSH Terms
Axons / metabolism
Corpus Striatum / drug effects*,  metabolism*
Excitatory Amino Acid Agonists / pharmacology
Immunohistochemistry / methods
Macrophages / metabolism
Myelin Sheath / metabolism*
N-Methylaspartate / pharmacology*
Neutrophils / metabolism
Rats, Wistar
Reg. No./Substance:
0/Excitatory Amino Acid Agonists; 6384-92-5/N-Methylaspartate

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