| Diffuse alveolar hemorrhage in acute promyelocytic leukemia patients treated with ATRA--a manifestation of the basic disease or the treatment. | |
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MedLine Citation:
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PMID: 11042521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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All-trans-retinoic acid (ATRA) is considered the recommended induction treatment for acute promyelocytic leukemia. In the pre-ATRA era pulmonary bleeding was a common cause of death in these patients, mostly due to disseminated intravascular coagulation which was further exacerbated by the administration of chemotherapy. Although ATRA syndrome, the most serious adverse effect of ATRA treatment, involves the lungs, pulmonary hemorrhage has only rarely been reported as a manifestation of ATRA syndrome. Here we describe 2 patients who developed diffuse alveolar hemorrhage during treatment with ATRA. The possible mechanisms of pulmonary bleeding in these cases are discussed. |
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Authors:
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P Raanani; E Segal; I Levi; M Bercowicz; H Berkenstat; A Avigdor; A Perel; I Ben-Bassat |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 37 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2000 May |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2003-06-23 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: Switzerland |
Other Details:
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Languages: eng Pagination: 605-10 Citation Subset: IM |
Affiliation:
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Institute of Hematology, The Chaim Sheba Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel. praanani@netvision.net.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / adverse effects*, therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use Blood Coagulation Tests Cytarabine / administration & dosage Daunorubicin / administration & dosage Dyspnea / chemically induced Fatal Outcome Fever / chemically induced Hemorrhage / chemically induced, etiology* Humans Leukemia, Promyelocytic, Acute / complications, drug therapy* Lung Diseases / chemically induced, etiology* Male Middle Aged Pulmonary Alveoli / drug effects Remission Induction Syndrome Tretinoin / administration & dosage, adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 147-94-4/Cytarabine; 20830-81-3/Daunorubicin; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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