Document Detail


Diffuse alveolar hemorrhage after infliximab treatment of Crohn's disease.
MedLine Citation:
PMID:  15290924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infliximab (Remicade), a chimeric monoclonal antibody to tumor necrosis factor-alpha (anti-TNF-alpha), is being used with increasing frequency in the treatment of Crohn's disease. Infliximab's safety profile to date has been good with reported adverse events being mild to moderate. We report a case of diffuse alveolar hemorrhage after the second infliximab infusion in a patient with Crohn's disease. The mechanism by which infliximab may have caused the observed pulmonary insult remains unknown. Physicians should be aware of the possible association between infliximab treatment and the development of alveolar hemorrhage. Future cases should be reported.
Authors:
Sofia Panagi; Wojciech Palka; Burton I Korelitz; Metin Taskin; Klaus D Lessnau
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  10     ISSN:  1078-0998     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-08-04     Completed Date:  2004-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  274-7     Citation Subset:  IM    
Affiliation:
Sections of Gastroenterology and Pulmonary Medicine, Department of Medicine, Lenox Hill Hospital, and New York University School of Medicine, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal / adverse effects*,  therapeutic use
Crohn Disease / drug therapy*
Female
Gastrointestinal Agents / adverse effects*,  therapeutic use
Hemorrhage / chemically induced*
Humans
Pneumonia / chemically induced,  diagnosis
Pulmonary Alveoli* / pathology
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Gastrointestinal Agents; 0/infliximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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