Document Detail

Diffuse Large B Cell Lymphoma Complicating Total Knee Arthroplasty: Case Report and Literature Review of the Association of Diffuse Large B Cell Lymphoma with Joint Replacement.
MedLine Citation:
PMID:  21734365     Owner:  NLM     Status:  Publisher    
Primary lymphoma of bone is extremely rare. There are increasing reports of lymphoma arising in bone adjacent to metallic prostheses. Herein, we describe the case of a 76-year-old man who developed diffuse large B cell lymphoma in the tibia 3 years after total knee arthroplasty for osteoarthritis. A review of the literature has identified 11 other cases of lymphoma arising in the context of orthopaedic metallic implants. To our knowledge this is the first reported case of a primary lymphoma arising in bone adjacent to a knee prosthesis. Possible pathogenetic mechanisms may include chronic antigenic stimulation of lymphocytes, proliferation of EBV-infected B lymphocytes, and direct mutagenic effects of metallic ions. Further research is required to investigate this intriguing link between metallic orthopaedic prostheses and localized lymphoma.
Mohammed Suhail Chaudhry; Harriet Mather; Alexandra Marks; Kikkeri Naresh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-07
Journal Detail:
Title:  Acta haematologica     Volume:  126     ISSN:  1421-9662     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  141-146     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Department of Haematology, Hammersmith Hospital, London, UK.
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