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Diffuse Infantile Hepatic Hemangiomas: A Report of Four Cases Successfully Managed with Medical Therapy.
MedLine Citation:
PMID:  21517953     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  We report four cases of diffuse infantile hepatic hemangioma, a rare but potentially life-threatening subset of hepatic hemangiomas. All patients demonstrated distinctive dome-shaped red-purple cutaneous hemangiomas. Two patients responded to steroids and propranolol (one in combination with vincristine), and two responded to steroids and vincristine. After a systematic literature review, we identified 26 previously reported cases of diffuse infantile hepatic hemangioma. Diffuse infantile hepatic hemangioma had a mortality rate of 17% and a >70% incidence of hypothyroidism, often severe (n = 30). More than one-third of patients developed heart failure (high output in half the cases). Based on our experience, early aggressive medical management, as well as thyroid replacement when indicated, should be initiated early in the course of diffuse infantile hepatic hemangioma pending evaluation for liver transplant.
Authors:
Iwei Yeh; Anna L Bruckner; Rosa Sanchez; Michael R Jeng; Brandon D Newell; Ilona J Frieden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-26
Journal Detail:
Title:  Pediatric dermatology     Volume:  -     ISSN:  1525-1470     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
Departments of Pathology and Dermatology, University of California San Francisco, San Francisco, California Departments of Dermatology and Pediatrics, School of Medicine, Stanford University, Stanford, California, Blood Systems Research Institute, Department of Laboratory Medicine, University of California San Francisco, San Francisco, California Division of Hematology/Oncology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City, Section of Dermatology, Kansas City, Missouri Departments of Dermatology and Pediatrics, University of California, San Francisco, California.
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