Document Detail

Diffuse Coronary Ectasia Complicated by Myocardial Infarction in a Patient with Multiple Sclerosis-Transradial Dethrombosis and One-year Coronary Computed Tomography Angiography Follow-Up.
MedLine Citation:
PMID:  21823078     Owner:  NLM     Status:  In-Data-Review    
Coronary artery ectasia (CAE) is frequently considered an incidental finding during coronary angiography, however, several reports have shown an association with myocardial ischemia and infarction. When acute myocardial infarction (AMI) occurs in cases of CAE, current reperfusion therapies, due to the large arterial size and the massive intracoronary thrombus, when used alone are limited in preventing the development of distal embolization and 'no reflow phenomenon.' In this article, we described the case of a multiple sclerosis (MS) patient with diffuse CAE and ST elevation AMI, treated by coronary dethrombosis multistrategy (mechanical and pharmacologic) during a transradial primary angioplasty. The higher thrombotic burden in MS with CAE was analyzed and possible common pathophysiologic pathways were discovered in the imbalance between proteolytic activities of metalloproteinases and endogenous tissue inhibitor, with subsequent increased proteolysis leading to a risk for coronary plaque rupture. The one-year clinical and angiographic follow-up with coronary computed tomography (CT) angiography, together with long-term antiplatelet therapy, was also evaluated.
Francesco Summaria;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American heart hospital journal     Volume:  9     ISSN:  1751-7168     ISO Abbreviation:  Am Heart Hosp J     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156064     Medline TA:  Am Heart Hosp J     Country:  England    
Other Details:
Languages:  eng     Pagination:  E48-51     Citation Subset:  IM    
Interventional Cardiologist, Department of Cardiology, Policlinico Casilino, Via Casilina, 1049 00169, Rome, Italy. E:
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Francesco Summaria / ; Marina Mustilli / ; Chiara Lanzillo / ; Enrico Romagnoli /

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