Document Detail


Difficulty in improving malnutrition and low-grade inflammation in diabetic patients on peritoneal dialysis.
MedLine Citation:
PMID:  19140846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuous ambulatory peritoneal dialysis (CAPD) is commonly used for renal replacement therapy in diabetes mellitus (DM) patients. We investigated the changes of peritoneal transport characteristics, nutritional status, and adequacy and inflammation parameters in diabetic CAPD patients (N = 17) compared to non-diabetic patients (N = 23). Peritoneal equilibrium testing, nutritional, biochemical, and anthropometric parameters and adequacy were prospectively assessed at 1 (baseline), 6 and 12 months after initiating CAPD. The levels of several nutritional parameters were lower and did not change in DM patients over time (P < 0.05) and significantly improved in the non-DM patients over time (P < 0.05). Total weekly creatinine clearance and residual renal function exhibited a rapid decline (P < 0.05) and inflammation parameter levels were higher in DM patients (P < 0.05). Our results showed the difficulty in improvement of nutritional status and inflammatory parameters in diabetic patients during at least the first year of CAPD compared to non-DM patients.
Authors:
Sung-Won Park; Jung-Ju Seo; Ho-Sang Bae; Jong-Yeon Kim; Chan-Duck Kim; Sun-Hee Park; Yong-Lim Kim
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  12     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-14     Completed Date:  2009-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  475-83     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Kyungpook University Hospital, Daegu, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Creatinine / blood,  urine
Diabetic Nephropathies / physiopathology*
Female
Follow-Up Studies
Humans
Inflammation / etiology,  physiopathology
Kidney Failure, Chronic / etiology*,  therapy
Kidney Function Tests
Male
Malnutrition / epidemiology,  etiology
Middle Aged
Nutritional Status*
Peritoneal Dialysis, Continuous Ambulatory*
Peritoneum / metabolism
Prospective Studies
Time Factors
Young Adult
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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