Document Detail

Difficulty diagnosing chronic cryptococcal meningitis in idiopathic CD4(+) lymphocytopenia.
MedLine Citation:
PMID:  21384279     Owner:  NLM     Status:  Publisher    
A 64-year-old man with idiopathic CD4(+) lymphocytopenia developed cognitive impairment and gait ataxia with isolated obstructive hydrocephalus, which was fatal. Cerebrospinal fluid showed mild pleocytosis, but the etiology was not revealed by extensive analysis. At autopsy, inflammatory cells, CD8(+) lymphocytes and abundant macrophages but not CD4(+) lymphocytes were infiltrating the meninges at the base of the brain. Electron microscopy demonstrated that inflammation was caused by Cryptococcus neoformans, which was localized exclusively within macrophages, where it grew with budding. Our study suggests that, in idiopathic CD4(+) lymphocytopenia, macrophages can efficiently phagocytize but inefficiently digest C. neoformans, thus representing a vehicle of chronic intracellular infection.
Giuseppe Sancesario; Giampiero Palmieri; Gemma Viola; Carla Fontana; Alessandra Perfetti; Lucia Anemona; Roberto Floris; Simone Marziali; Giorgio Bernardi; Luigi Giusto Spagnoli
Related Documents :
16183209 - The role of hla-g in cytokine homeostasis during early pregnancy complicated with mater...
18567869 - Cd4+ t cells and cytokines in the pathogenesis of acquired myasthenia gravis.
20055739 - Role of glycogen synthase kinase 3 (gsk-3) in innate immune response of human immature ...
18254939 - An anti-inflammatory role for tranexamic acid in cardiac surgery?
18021769 - Cytokines and anti-cytokines as therapeutics--an update.
17023089 - Inhaled cytokines and cytokine antagonists.
15816829 - Differential activation profiles of multiple transcription factors during dendritic cel...
17543969 - The amastigote forms of leishmania are experts at exploiting host cell processes to est...
18701209 - Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with co...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-8
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  -     ISSN:  1590-3478     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Dipartimento di Neuroscienze, Università di Roma Tor Vergata, Via Montpellier 1, 00133, Rome, Italy,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute disseminated encephalomyelitis associated with Influenza A H1N1 infection.
Next Document:  Increased incidence of pre-diabetes mellitus at a department of rheumatology: a retrospective study.