Document Detail

Difficulties in the treatment of intestinal amoebiasis in mentally disabled individuals at a rehabilitation institution for the intellectually impaired in Japan.
MedLine Citation:
PMID:  20720419     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments.
METHODS: Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy in mentally disabled individuals infected with E. histolytica at an institution (the prevalence rate and positive serology rate were 38.2 and 67.1%, respectively). The therapeutic effect of the drugs was judged by microscopic stool examination and an E. histolytica antigen detection kit.
RESULTS: The mass infection was eliminated through the administration of metronidazole and subsequent use of diloxanide furoate.
CONCLUSIONS: Combination therapy successfully cured and prevented transmission of the mass E. histolytica infection at the institution.
Tsukasa Fujishima; Shoichi Nishise; Masahiro Ichihara; Seiki Kobayashi; Tsutomu Takeuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-18
Journal Detail:
Title:  Chemotherapy     Volume:  56     ISSN:  1421-9794     ISO Abbreviation:  Chemotherapy     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  348-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Division of Surgery, Shirataka Town Hospital, Shirataka, Japan.
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MeSH Terms
Amebicides / therapeutic use*
Drug Resistance
Drug Therapy, Combination
Dysentery, Amebic / drug therapy*,  epidemiology,  parasitology
Entamoeba histolytica / drug effects*,  genetics,  immunology
Enzyme-Linked Immunosorbent Assay
Feces / parasitology
Furans / therapeutic use*
Japan / epidemiology
Mentally Disabled Persons*
Metronidazole / therapeutic use*
Rehabilitation Centers
Treatment Outcome
Reg. No./Substance:
0/Amebicides; 0/Furans; 3736-81-0/diloxanide furoate; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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