Document Detail


Difficult treatment issues in sarcoidosis.
MedLine Citation:
PMID:  12588537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The management of sarcoidosis includes several crucial decisions. Not all patients with sarcoidosis need treatment. At least a third of patients will never be treated. It is unclear whether asymptomatic patients ever need therapy, even if they have extensive lung disease. One reason that clinicians are reluctant to start therapy is that many patients who are started on corticosteroids have a difficult time getting off therapy, even after 2 years. In the chronic patient, alternatives to corticosteroids have been developed. These include drugs such as methotrexate, azathioprine and hydroxychloroquine. These agents have been the standard second line of therapy for patients with chronic disease. However, these drugs do not always work. In addition, they are associated with their own toxicities. Another group of sarcoidosis patients have also emerged. These are the refractory patients, who have progressive disease whilst on therapy. For these patients, new agents such as thalidomide and the monoclonal antibodies to tumour necrosis factor have been occasionally helpful. This paper reviews several important issues in the management of sarcoidosis.
Authors:
R P Baughman; J P Lynch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of internal medicine     Volume:  253     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-17     Completed Date:  2003-03-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Interstitial Lung Disease and Sarcoidosis Clinic, University of Cincinnati, Cincinnati, OH 45267-0564, USA. baughmrp@ucmail.uc.edu
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / therapeutic use
Antimalarials / therapeutic use
Azathioprine / therapeutic use
Cyclophosphamide / therapeutic use
Decision Making
Humans
Immunosuppressive Agents / therapeutic use
Methotrexate / therapeutic use
Sarcoidosis / drug therapy*
Thalidomide / therapeutic use
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antimalarials; 0/Immunosuppressive Agents; 0/infliximab; 446-86-6/Azathioprine; 50-18-0/Cyclophosphamide; 50-35-1/Thalidomide; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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