Document Detail

Differing patterns of methotrexate use for psoriatic disease amongst dermatologists and rheumatologists.
MedLine Citation:
PMID:  22309601     Owner:  NLM     Status:  Publisher    
Background:  Methotrexate (MTX) is commonly used by dermatologists in treatment of psoriasis (PsO) and by rheumatologists for psoriatic arthritis (PsA) and rheumatoid arthritis (RA). Guidelines on MTX use have been published in both specialties yet current use patterns remain unknown. Objective:  This study examined MTX use amongst Canadian dermatologists and rheumatologists. Methods:  An online survey was made available to 414 Canadian dermatologists and 415 Canadian rheumatologists. The survey asked about MTX use in treatment of PsO and PsA with topics specific to administration and use with biologics. Herein, we focus on MTX use in PsO. Results:  In PsO, the majority of dermatologists (97%) and rheumatologists (80%) initiated MTX therapy with oral tablets. Fewer dermatologists (49%) than rheumatologists (96%) switched to parenteral MTX; in those who switched, 63% of dermatologists and 98% of rheumatologists preferred switching to subcutaneous (SC) injections. When adding biologics, 81% of dermatologists discontinued MTX while 93% of rheumatologists continued MTX therapy. All differences were significant, p≤0.05. Conclusions:  The majority of dermatologists and rheumatologists are similar in their initial use of MTX in PsO but differ in how they proceed with therapy. The use of SC MTX and MTX combination therapy in PsO requires further investigation.
E C Dupuis; V M Bhole; J P Dutz
Publication Detail:
Type:  LETTER     Date:  2012-2-6
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 British Association of Dermatologists.
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada Department of Dermatology and Skin Science, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
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