| Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension. | |
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MedLine Citation:
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PMID: 17909120 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension in normal-weight and obese individuals is characterized by activation of the sympathetic nervous system. Measurement of spillover of the sympathetic transmitter, norepinephrine, to plasma indicates that the regional pattern of sympathetic activation in the 2 "variants" of essential hypertension differs, excluding the heart in obesity-related hypertension. Whether sympathetic nerve firing characteristics also differ is unknown. We studied multiunit and single fiber sympathetic nerve firing properties in patients with normal-weight hypertension and obesity-related hypertension, comparing these with nerve characteristics in normal-weight and obese people with normal blood pressure. Both normal-weight hypertensive (n=10) and obese hypertensive (n=14) patients had increased total multiunit muscle sympathetic nerve activity compared with the normal-weight (n=11) and obese (n=11) people with normal blood pressure (65+/-4 versus 47+/-6 bursts per 100 heartbeats, P<0.01 in the normal-weight groups and 68+/-4 versus 53+/-3 bursts per 100 beats, P<0.01 in the obese groups). Sympathetic activation in normal-weight hypertension was characterized by increased firing rate of single vasoconstrictor fibers (70+/-8 versus 28+/-3 spikes per 100 beats; P<0.001), increased firing probability per heartbeat (39+/-3% versus 20+/-3%; P<0.001), and higher incidence of multiple spikes per heartbeat (30+/-4% versus 17+/-4%; P<0.05). Sympathetic activation in obesity-related hypertension differed, involving recruitment of previously silent fibers, which fired at a normal rate. The pattern of sympathetic activation in normal-weight and obesity-related hypertension differs in terms of both the firing characteristics of individual sympathetic fibers and the sympathetic outflows involved. The underlying central nervous system mechanism and the adverse consequences of the 2 modes of sympathetic activation may differ. |
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Authors:
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Elisabeth Lambert; Nora Straznicky; Markus Schlaich; Murray Esler; Tye Dawood; Elodie Hotchkin; Gavin Lambert |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-01 |
Journal Detail:
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Title: Hypertension Volume: 50 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-18 Completed Date: 2007-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 862-8 Citation Subset: IM |
Affiliation:
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Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia. Elisabeth.lambert@baker.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Adult Aged Blood Pressure Electrocardiography Electrophysiology Female Heart Rate Humans Hypertension / complications, physiopathology* Male Microelectrodes Middle Aged Obesity / complications, physiopathology* Peroneal Nerve / physiopathology Sympathetic Fibers, Postganglionic / physiopathology Sympathetic Nervous System / physiopathology* Thinness / physiopathology* |
| Comments/Corrections | |
Comment In:
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Hypertension. 2007 Nov;50(5):835-6
[PMID:
17909119
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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