Document Detail

Differing effects of delta-9-tetrahydrocannabinol (THC) on murine spleen cell populations dependent upon stimulators.
MedLine Citation:
PMID:  1330945     Owner:  NLM     Status:  MEDLINE    
Delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, can suppress the immune response, both in vitro and in vivo. In the present study, THC was found to either up-regulate or down-regulate lymphocytes depending on the method of stimulation. When the mitogens concanavalin A (Con A) or phytohemagglutinin (PHA) were used to stimulate THC-treated splenocytes, a down-regulation of lymphocyte proliferation occurred, which reflected lower T-cell numbers in general and Ly2 positive cells specifically. When splenocytes were stimulated directly by using anti-CD3 antibody it was found that low concentrations of THC enhanced lymphocyte proliferation, T-cell numbers in general, and Ly2 cells specifically. These results emphasize that THC can either enhance or suppress aspects of the immune response, depending on the specific immune stimulants used and the specific parameter of immunity measured.
S H Pross; Y Nakano; R Widen; S McHugh; C A Newton; T W Klein; H Friedman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of immunopharmacology     Volume:  14     ISSN:  0192-0561     ISO Abbreviation:  Int. J. Immunopharmacol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7904799     Medline TA:  Int J Immunopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1019-27     Citation Subset:  IM    
University of South Florida College of Medicine, Tampa 33612.
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MeSH Terms
Adjuvants, Immunologic / pharmacology*
Antigens, CD3 / physiology
Concanavalin A
Lymphocyte Activation / drug effects
Mice, Inbred BALB C
Spleen / cytology,  drug effects*
T-Lymphocytes / drug effects
Tetrahydrocannabinol / pharmacology*
Grant Support
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antigens, CD3; 0/Phytohemagglutinins; 11028-71-0/Concanavalin A; 1972-08-3/Tetrahydrocannabinol

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