Document Detail


Differing effects of acute and chronic stressors on plasma osteocalcin and leptin in rats.
MedLine Citation:
PMID:  17514585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stressor activation of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis can have profound effects on bone and also appetite and metabolism. We tested in rats the response of plasma osteocalcin (pOC, a bone biomarker that is acutely stress responsive), corticosterone, and leptin to (1) ethanol consumption (5% w/v) in a liquid diet (compared with ad libitum and pair-fed rats), (2) acute restraint, and (3) acute (once, 1 h) and (4) chronic (1 h/day for 7 weeks) social aggression. Basal pOC concentration did not differ with ethanol diet or social interaction, but was elevated by both foot restraint immobilization (Imo) and restraint in wire mesh cylinders (WMR). As previously reported for chronic Imo, ingestion of ethanol blunted the pOC response to Imo. Plasma corticosterone concentration was increased by acute WMR and acute social interaction but was unaltered by chronic social interaction. Plasma leptin concentration was markedly increased by Imo in ad libitum fed, but only slightly in ethanol or pair-fed rats. In contrast, the data reflect significant differences between acute and chronic stressor effects since chronic social stress had little effect on pOC or plasma corticosterone, but tended to decrease leptin level in relation to dominance. Lack of significant impact of prolonged ethanol intake or social aggression suggests physiological adaptation.
Authors:
P Patterson-Buckendahl; L A Pohorecky; R Kvetnansky
Related Documents :
9397975 - The effects of low dietary levels of polyunsaturates on alcohol-induced liver disease i...
3978155 - Prenatal alcohol exposure: abnormalities in placental growth and fetal amino acid uptak...
3209335 - Multivariate analysis of dietary patterns in 939 swiss adults: sociodemographic paramet...
18455245 - Altered water-maze search behavior in adult guinea pigs following chronic prenatal etha...
2612535 - Activated charcoal in the treatment of hypercholesterolaemia: dose-response relationshi...
1861925 - Hypercholesterolemia in adolescents: effectiveness of screening strategies based on sel...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  10     ISSN:  1025-3890     ISO Abbreviation:  Stress     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-07-26     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  163-72     Citation Subset:  IM    
Affiliation:
Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway, NJ 05584, USA. larissa@rci.rutgers.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / adverse effects
Animals
Behavior, Animal
Corticosterone / blood
Hierarchy, Social
Leptin / blood*
Male
Osteocalcin / blood*
Rats
Rats, Sprague-Dawley
Restraint, Physical
Stress, Psychological
Grant Support
ID/Acronym/Agency:
R21 AA 12705-01/AA/NIAAA NIH HHS; R21 AA 14399-01A2/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Leptin; 104982-03-8/Osteocalcin; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Negative regulation of corticotropin releasing factor expression and limitation of stress response.
Next Document:  Adrenergic and calcium modulation of the heart in stress: from molecular biology to function.