Document Detail

Differing effects of acute and chronic stressors on plasma osteocalcin and leptin in rats.
MedLine Citation:
PMID:  17514585     Owner:  NLM     Status:  MEDLINE    
Stressor activation of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis can have profound effects on bone and also appetite and metabolism. We tested in rats the response of plasma osteocalcin (pOC, a bone biomarker that is acutely stress responsive), corticosterone, and leptin to (1) ethanol consumption (5% w/v) in a liquid diet (compared with ad libitum and pair-fed rats), (2) acute restraint, and (3) acute (once, 1 h) and (4) chronic (1 h/day for 7 weeks) social aggression. Basal pOC concentration did not differ with ethanol diet or social interaction, but was elevated by both foot restraint immobilization (Imo) and restraint in wire mesh cylinders (WMR). As previously reported for chronic Imo, ingestion of ethanol blunted the pOC response to Imo. Plasma corticosterone concentration was increased by acute WMR and acute social interaction but was unaltered by chronic social interaction. Plasma leptin concentration was markedly increased by Imo in ad libitum fed, but only slightly in ethanol or pair-fed rats. In contrast, the data reflect significant differences between acute and chronic stressor effects since chronic social stress had little effect on pOC or plasma corticosterone, but tended to decrease leptin level in relation to dominance. Lack of significant impact of prolonged ethanol intake or social aggression suggests physiological adaptation.
P Patterson-Buckendahl; L A Pohorecky; R Kvetnansky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  10     ISSN:  1025-3890     ISO Abbreviation:  Stress     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-07-26     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  163-72     Citation Subset:  IM    
Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway, NJ 05584, USA.
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MeSH Terms
Alcohol Drinking / adverse effects
Behavior, Animal
Corticosterone / blood
Hierarchy, Social
Leptin / blood*
Osteocalcin / blood*
Rats, Sprague-Dawley
Restraint, Physical
Stress, Psychological
Grant Support
R21 AA 12705-01/AA/NIAAA NIH HHS; R21 AA 14399-01A2/AA/NIAAA NIH HHS
Reg. No./Substance:
0/Leptin; 104982-03-8/Osteocalcin; 50-22-6/Corticosterone

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