| Differing effect of protein isolates from different cultivars of blue lupin on plasma lipoproteins of hypercholesterolemic rats. | |
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MedLine Citation:
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PMID: 19060384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and alpha-/beta-conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed with TPE from Vitabor and alpha-/beta-conglutin had lower triglyceride concentrations in the plasma (-24% and -21%, respectively) and very-low-density lipoprotein (VLDL; -40% and -29%, respectively) than the rats fed with casein. TPE from Vitabor was also capable of lowering low-density lipoprotein (LDL) cholesterol (-37%). In the liver of the rats fed with TPE from Vitabor, the expression of the genes involved in triglyceride and cholesterol synthesis was down-regulated. This study shows that the Vitabor cultivar of blue lupin had the most beneficial effect on plasma lipids which was presumed to have been caused by the down-regulation of genes involved in lipid synthesis. |
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Authors:
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Anja Bettzieche; Corinna Brandsch; Manja Schmidt; Kristin Weisse; Klaus Eder; Gabriele I Stangl |
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Publication Detail:
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Type: Journal Article Date: 2008-12-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 72 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-24 Completed Date: 2009-02-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 3114-21 Citation Subset: IM |
Affiliation:
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Institute of Agricultural and Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / genetics, metabolism Body Weight / drug effects Cholesterol / blood, genetics Gene Expression Regulation / drug effects Hypercholesterolemia / blood*, drug therapy, pathology Lipoproteins / blood* Liver / drug effects, pathology Lupinus / chemistry* Male Organ Size / drug effects Plant Proteins / isolation & purification*, pharmacology*, therapeutic use RNA, Messenger / genetics, metabolism Rats Rats, Sprague-Dawley Triglycerides / blood, genetics |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Lipoproteins; 0/Plant Proteins; 0/RNA, Messenger; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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