Document Detail

A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure.
MedLine Citation:
PMID:  22961867     Owner:  NLM     Status:  MEDLINE    
This study sought to characterize the role of free radicals in regulating central and peripheral hemodynamics at rest and during exercise in patients with heart failure (HF). We examined cardiovascular responses to dynamic handgrip exercise (4, 8, and 12 kg at 1 Hz) following consumption of either a placebo or acute oral antioxidant cocktail (AOC) consisting of vitamin C, E, and α-lipoic acid in a balanced, crossover design. Central and peripheral hemodynamics, mean arterial pressure, cardiac index, systemic vascular resistance (SVR), brachial artery blood flow, and peripheral (arm) vascular resistance (PVR) were determined in 10 HF patients and 10 age-matched controls. Blood assays evaluated markers of oxidative stress and efficacy of the AOC. When compared with controls, patients with HF exhibited greater oxidative stress, measured by malondialdehyde (+36%), and evidence of endogenous antioxidant compensation, measured by greater superoxide dismutase activity (+83%). The AOC increased plasma ascorbate (+50%) in both the HF patients and controls, but significant systemic hemodynamic effects were only evident in the patients with HF, both at rest and throughout exercise. Specifically, the AOC reduced mean arterial pressure (-5%) and SVR (-12%) and increased cardiac index (+7%) at each workload. In contrast, peripherally, brachial artery blood flow and PVR (arm) were unchanged by the AOC. In conclusion, these data imply that SVR in patients with HF is, at least in part, mediated by oxidative stress. However, this finding does not appear to be the direct result of muscle-specific changes in PVR.
Melissa A H Witman; John McDaniel; Anette S Fjeldstad; Stephen J Ives; Jia Zhao; Jose N Nativi; Josef Stehlik; D Walter Wray; Russell S Richardson
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Webcasts     Date:  2012-09-07
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-17     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1237-44     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Antioxidants / administration & dosage
Arterial Pressure
Ascorbic Acid / administration & dosage,  blood
Biological Markers / blood
Blood Flow Velocity
Brachial Artery / physiopathology,  ultrasonography
Cross-Over Studies
Hand Strength
Heart Failure / metabolism,  physiopathology*,  ultrasonography
Hemodynamics* / drug effects
Malondialdehyde / blood
Middle Aged
Muscle Contraction
Muscle, Skeletal / metabolism*
Oxidative Stress* / drug effects
Regional Blood Flow
Single-Blind Method
Superoxide Dismutase / blood
Thioctic Acid / administration & dosage
Time Factors
Ultrasonography, Doppler
Vascular Resistance
Vitamin E / administration & dosage
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 1406-18-4/Vitamin E; 4Y8F71G49Q/Malondialdehyde; 73Y7P0K73Y/Thioctic Acid; EC Dismutase; PQ6CK8PD0R/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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