|A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure.|
|PMID: 22961867 Owner: NLM Status: MEDLINE|
|This study sought to characterize the role of free radicals in regulating central and peripheral hemodynamics at rest and during exercise in patients with heart failure (HF). We examined cardiovascular responses to dynamic handgrip exercise (4, 8, and 12 kg at 1 Hz) following consumption of either a placebo or acute oral antioxidant cocktail (AOC) consisting of vitamin C, E, and α-lipoic acid in a balanced, crossover design. Central and peripheral hemodynamics, mean arterial pressure, cardiac index, systemic vascular resistance (SVR), brachial artery blood flow, and peripheral (arm) vascular resistance (PVR) were determined in 10 HF patients and 10 age-matched controls. Blood assays evaluated markers of oxidative stress and efficacy of the AOC. When compared with controls, patients with HF exhibited greater oxidative stress, measured by malondialdehyde (+36%), and evidence of endogenous antioxidant compensation, measured by greater superoxide dismutase activity (+83%). The AOC increased plasma ascorbate (+50%) in both the HF patients and controls, but significant systemic hemodynamic effects were only evident in the patients with HF, both at rest and throughout exercise. Specifically, the AOC reduced mean arterial pressure (-5%) and SVR (-12%) and increased cardiac index (+7%) at each workload. In contrast, peripherally, brachial artery blood flow and PVR (arm) were unchanged by the AOC. In conclusion, these data imply that SVR in patients with HF is, at least in part, mediated by oxidative stress. However, this finding does not appear to be the direct result of muscle-specific changes in PVR.|
|Melissa A H Witman; John McDaniel; Anette S Fjeldstad; Stephen J Ives; Jia Zhao; Jose N Nativi; Josef Stehlik; D Walter Wray; Russell S Richardson|
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|Type: Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Webcasts Date: 2012-09-07|
|Title: American journal of physiology. Heart and circulatory physiology Volume: 303 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2012 Nov|
|Created Date: 2012-11-16 Completed Date: 2013-01-17 Revised Date: 2013-12-05|
Medline Journal Info:
|Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States|
|Languages: eng Pagination: H1237-44 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Antioxidants / administration & dosage
Ascorbic Acid / administration & dosage, blood
Biological Markers / blood
Blood Flow Velocity
Brachial Artery / physiopathology, ultrasonography
Heart Failure / metabolism, physiopathology*, ultrasonography
Hemodynamics* / drug effects
Malondialdehyde / blood
Muscle, Skeletal / metabolism*
Oxidative Stress* / drug effects
Regional Blood Flow
Superoxide Dismutase / blood
Thioctic Acid / administration & dosage
Vitamin E / administration & dosage
|P01-HL-091830/HL/NHLBI NIH HHS|
|0/Antioxidants; 0/Biological Markers; 1406-18-4/Vitamin E; 4Y8F71G49Q/Malondialdehyde; 73Y7P0K73Y/Thioctic Acid; EC 188.8.131.52/Superoxide Dismutase; PQ6CK8PD0R/Ascorbic Acid|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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