| Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. | |
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MedLine Citation:
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PMID: 19789240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate whether cerebral blood volume (CBV), peak height (PH), and percentage of signal intensity recovery (PSR) measurements derived from the results of T2-weighted dynamic susceptibility-weighted contrast material-enhanced (DSC) magnetic resonance (MR) imaging performed after external beam radiation therapy (EBRT) can be used to distinguish recurrent glioblastoma multiforme (GBM) from radiation necrosis. MATERIALS AND METHODS: Fifty-seven patients were enrolled in this HIPAA-compliant institutional review board-approved retrospective study after they received a diagnosis of GBM, underwent EBRT, and were examined with DSC MR imaging, which revealed progressive contrast enhancement within the radiation field. A definitive diagnosis was established at subsequent surgical resection or clinicoradiologic follow-up. Regions of interest were retrospectively drawn around the entire contrast-enhanced region. This created T2-weighted signal intensity-time curves that produced three cerebral hemodynamic MR imaging measurements: CBV, PH, and PSR. Welch t tests were used to compare measurements between groups. RESULTS: Mean, maximum, and minimum relative PH and relative CBV were significantly higher (P < .01) in patients with recurrent GBM than in patients with radiation necrosis. Mean, maximum, and minimum relative PSR values were significantly lower (P < .05) in patients with recurrent GBM than in patients with radiation necrosis. CONCLUSION: These findings suggest that DSC perfusion MR imaging may be used to differentiate recurrent GBM from EBRT-induced radiation necrosis. |
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Authors:
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Ramon F Barajas; Jamie S Chang; Mark R Segal; Andrew T Parsa; Michael W McDermott; Mitchel S Berger; Soonmee Cha |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-09-29 |
Journal Detail:
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Title: Radiology Volume: 253 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-29 Completed Date: 2009-12-01 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 486-96 Citation Subset: AIM; IM |
Copyright Information:
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(c) RSNA, 2009. |
Affiliation:
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Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Volume Brain / radiation effects* Brain Neoplasms / diagnosis*, radiotherapy* Cerebrovascular Circulation Contrast Media* Diagnosis, Differential Female Glioblastoma / diagnosis*, radiotherapy* Humans Image Processing, Computer-Assisted Magnetic Resonance Angiography* Male Middle Aged Necrosis Neoplasm Recurrence, Local / diagnosis* Radiation Injuries / diagnosis* Radiotherapy Dosage Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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NS045013/NS/NINDS NIH HHS; TL1 RR024129-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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