Document Detail


Differentiation pathways of ectodermal epithelial cells in hydra.
MedLine Citation:
PMID:  2451628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The differentiation pathways of ectodermal epithelial cells in hydra were investigated. We found that under steady state conditions the ectodermal epithelial cells of the foot, the foot mucous cells, and the ectodermal epithelial cells of the tentacles, the battery cells, differentiate from gastric ectodermal ephithelial stem cells. From stem cell to the terminally differentiated state, a single cell cycle is required. The cells undergo a final round of DNA replication, double their genome to 4 n and become arrested in the G2-phase of the cell cycle. The ectodermal ephithelial cells of the hypostome, which like the tentacle cells are part of the head structure, can also arise from gastric ectodermal epithelial stem cells, but do so only during head regeneration and budding. They differentiate from stem cell to hypostomal cell in a single cell cycle, but in contrast to foot mucous and battery cells they remain capable of cell proliferation. Due to this self-renewal potential, they do not require recruitment from the gastric stem-cell pool in steady-state animals.
Authors:
S Dübel; S A Hoffmeister; H C Schaller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  35     ISSN:  0301-4681     ISO Abbreviation:  Differentiation     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  181-9     Citation Subset:  IM    
Affiliation:
Zentrum für Molekulare Biologie Heidelberg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle
Cell Differentiation*
Cell Movement
Ectoderm / cytology*,  physiology
Epitopes
Hydra / cytology*,  physiology
Chemical
Reg. No./Substance:
0/Epitopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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