| Differentiation of osteoblast in vitro is regulated by progesterone. | |
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MedLine Citation:
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PMID: 9275698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation of cellular differentiation by progesterone in fetal rat calvarial osteoblasts was investigated. Our results showed that cells cultured in the presence of progesterone had a 7% increase in the alkaline phosphatase activity when compared to untreated cells. The concentration of osteocalcin in the conditioned medium from progesterone treated osteoblasts was 28% higher than that of untreated controls. In addition, administration of progesterone significantly enhanced the number and area of bone nodules. In conclusion, progesterone stimulates the differentiation of fetal rat calvarial osteoblastic cells in vitro. |
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Authors:
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L Chen; N T Foged |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Volume: 16 ISSN: 0257-716X ISO Abbreviation: J. Tongji Med. Univ. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-10-09 Completed Date: 1997-10-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8605495 Medline TA: J Tongji Med Univ Country: CHINA |
Other Details:
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Languages: eng Pagination: 83-6 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Xiehe Hospital, Tongji Medical University, Wuhan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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metabolism Animals Cell Differentiation / drug effects Cells, Cultured Fetus Osteoblasts / cytology* Osteocalcin / analysis Progesterone / pharmacology* Rats Rats, Sprague-Dawley Skull |
| Chemical | |
Reg. No./Substance:
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104982-03-8/Osteocalcin; 57-83-0/Progesterone; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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