Document Detail


Differentiation of mouth versus gut as site of origin of odoriferous breath gases after garlic ingestion.
MedLine Citation:
PMID:  9950816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Utilizing the sulfur-containing gases of garlic as probes, we investigated the gut versus mouth origin of odoriferous breath gases. Five individuals ingested 6 g of garlic, and sulfur gases in mouth, alveolar air, and urine samples were measured. The mouth normally contained low concentrations of hydrogen sulfide, methanethiol, and dimethyl sulfide. Immediately after garlic ingestion, transient high concentrations of methanethiol and allyl mercaptan and lesser concentrations of allyl methyl sulfide (AMS), allyl methyl disulfide, and allyl disulfide were observed. With the exception of AMS, all gases were present in far greater concentrations in mouth than alveolar air, indicating an oral origin. Only AMS was of gut origin as evidenced by similar partial pressures in mouth, alveolar air, and urine. After 3 h, AMS was the predominant breath sulfur gas. The unique derivation of AMS from the gut is attributable to the lack of gut and liver metabolism of this gas versus the rapid metabolism of the other gases. Breath odor after garlic ingestion initially originates from the mouth and subsequently from the gut.
Authors:
F Suarez; J Springfield; J Furne; M Levitt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  276     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-30     Completed Date:  1999-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G425-30     Citation Subset:  IM    
Affiliation:
Research Department, Minneapolis Veterans Affairs Medical Center and Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Eating* / physiology
Female
Garlic*
Gases
Halitosis / etiology*
Humans
Intestines / metabolism,  physiology*
Male
Middle Aged
Mouth / metabolism,  physiology*
Osmolar Concentration
Plants, Medicinal*
Pulmonary Alveoli / physiology
Sulfur Compounds / metabolism,  urine
Grant Support
ID/Acronym/Agency:
R01-DK-13093025/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Gases; 0/Sulfur Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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