| Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study. | |
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MedLine Citation:
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PMID: 2536795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primitive macrophages first appear in the blood islands of the mouse yolk sac on the ninth day of gestation. After the tenth day of fetal life, these cells differentiate into fetal macrophages and become mature, with the development of intracellular organelles. They appear in the mesenchymal layer and further immigrate into the extraembryonic coelom. The fetal macrophages do not show any cytochemical peroxidase or 5'-nucleotidase activity, and they possess a marked proliferative capacity. Promonocytes or monocytes that have an incomplete ultrastructure emerge in the blood islands of the yolk sac a day after the occurrence of the fetal macrophages. These events suggest that fetal macrophages differentiate from primitive macrophages before the development of promonocytes or monocytes in the mouse yolk sac; they actively proliferate and are colonized into the embryonic tissues. These results also indicate that the ontogeny of the monocyte/macrophage is different in the early embryo compared with its later developmental stages. |
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Authors:
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K Takahashi; F Yamamura; M Naito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 45 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-03-21 Completed Date: 1989-03-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 87-96 Citation Subset: IM |
Affiliation:
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Second Department of Pathology, Kumamoto University Medical School, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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5'-Nucleotidase Animals Cell Adhesion Cell Differentiation Cell Division Embryonic and Fetal Development* Female Immunohistochemistry Macrophages / enzymology, physiology*, ultrastructure Mice Mice, Inbred C3H Microscopy, Electron Naphthol AS D Esterase / analysis Nucleotidases / analysis Peroxidase / analysis Pregnancy Yolk Sac / physiology*, ultrastructure |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.7/Peroxidase; EC 3.1.-/Naphthol AS D Esterase; EC 3.1.3.-/Nucleotidases; EC 3.1.3.5/5'-Nucleotidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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