Document Detail


Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study.
MedLine Citation:
PMID:  2536795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primitive macrophages first appear in the blood islands of the mouse yolk sac on the ninth day of gestation. After the tenth day of fetal life, these cells differentiate into fetal macrophages and become mature, with the development of intracellular organelles. They appear in the mesenchymal layer and further immigrate into the extraembryonic coelom. The fetal macrophages do not show any cytochemical peroxidase or 5'-nucleotidase activity, and they possess a marked proliferative capacity. Promonocytes or monocytes that have an incomplete ultrastructure emerge in the blood islands of the yolk sac a day after the occurrence of the fetal macrophages. These events suggest that fetal macrophages differentiate from primitive macrophages before the development of promonocytes or monocytes in the mouse yolk sac; they actively proliferate and are colonized into the embryonic tissues. These results also indicate that the ontogeny of the monocyte/macrophage is different in the early embryo compared with its later developmental stages.
Authors:
K Takahashi; F Yamamura; M Naito
Related Documents :
18657635 - Protein expression pattern of murine macrophages treated with anthrax lethal toxin.
8286145 - Macrophage heterogeneity in development and differentiation.
7095825 - What is the relevance of exudate-resident macrophages?
6186805 - Flow cytometric analysis of macrophage heterogeneity and differentiation: utilization o...
22629255 - Therapeutic potential of semi-mature dendritic cells for tolerance induction.
17167855 - Overexpression of caspase-9 triggers its activation and apoptosis in vitro.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  45     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-21     Completed Date:  1989-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-96     Citation Subset:  IM    
Affiliation:
Second Department of Pathology, Kumamoto University Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
5'-Nucleotidase
Animals
Cell Adhesion
Cell Differentiation
Cell Division
Embryonic and Fetal Development*
Female
Immunohistochemistry
Macrophages / enzymology,  physiology*,  ultrastructure
Mice
Mice, Inbred C3H
Microscopy, Electron
Naphthol AS D Esterase / analysis
Nucleotidases / analysis
Peroxidase / analysis
Pregnancy
Yolk Sac / physiology*,  ultrastructure
Chemical
Reg. No./Substance:
EC 1.11.1.7/Peroxidase; EC 3.1.-/Naphthol AS D Esterase; EC 3.1.3.-/Nucleotidases; EC 3.1.3.5/5'-Nucleotidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stimulation of granulocytic cell iodination by pine cone antitumor substances.
Next Document:  Excitation of skinned muscle fibers by imposed ion gradients. IV. Effects of stretch and perchlorate...