Document Detail

Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study.
MedLine Citation:
PMID:  2536795     Owner:  NLM     Status:  MEDLINE    
Primitive macrophages first appear in the blood islands of the mouse yolk sac on the ninth day of gestation. After the tenth day of fetal life, these cells differentiate into fetal macrophages and become mature, with the development of intracellular organelles. They appear in the mesenchymal layer and further immigrate into the extraembryonic coelom. The fetal macrophages do not show any cytochemical peroxidase or 5'-nucleotidase activity, and they possess a marked proliferative capacity. Promonocytes or monocytes that have an incomplete ultrastructure emerge in the blood islands of the yolk sac a day after the occurrence of the fetal macrophages. These events suggest that fetal macrophages differentiate from primitive macrophages before the development of promonocytes or monocytes in the mouse yolk sac; they actively proliferate and are colonized into the embryonic tissues. These results also indicate that the ontogeny of the monocyte/macrophage is different in the early embryo compared with its later developmental stages.
K Takahashi; F Yamamura; M Naito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  45     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-21     Completed Date:  1989-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-96     Citation Subset:  IM    
Second Department of Pathology, Kumamoto University Medical School, Japan.
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MeSH Terms
Cell Adhesion
Cell Differentiation
Cell Division
Embryonic and Fetal Development*
Macrophages / enzymology,  physiology*,  ultrastructure
Mice, Inbred C3H
Microscopy, Electron
Naphthol AS D Esterase / analysis
Nucleotidases / analysis
Peroxidase / analysis
Yolk Sac / physiology*,  ultrastructure
Reg. No./Substance:
EC; EC 3.1.-/Naphthol AS D Esterase; EC 3.1.3.-/Nucleotidases; EC'-Nucleotidase

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