Document Detail

Differentiation-inducing and protective effects of adult rat olfactory ensheathing cell conditioned medium on PC12 cells.
MedLine Citation:
PMID:  12850535     Owner:  NLM     Status:  MEDLINE    
Transplantation of olfactory ensheathing cells has been one of the promising strategies in enhancing central nerve fiber regeneration. Membrane surface molecules on olfactory ensheathing cells mediating cell-cell interactions as well as various factors released from them are thought to be important for nerve regeneration. The latter, however, has not been fully substantiated by experimental data, particularly regarding the olfactory ensheathing cells of the adult animals. In the present study, the effects of adult olfactory ensheathing cell conditioned medium on PC12 cells were examined. The results show that the factors secreted by the adult olfactory ensheathing cells can promote PC12 cell differentiation and protect it from Zn(2+) insult.
Ya-Zhou Wang; Jin-Hong Meng; Hao Yang; Na Luo; Xi-Ying Jiao; Gong Ju
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  346     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2003-09-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Institute of Neurosciences, The Fourth Military Medical University, 17 Chang Le Xi Road, Xi'an, 710032, PR China.
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MeSH Terms
Cell Differentiation / drug effects*,  physiology
Culture Media, Conditioned / pharmacology
Cytoprotection / drug effects*,  physiology
Olfactory Mucosa / cytology*,  drug effects*
PC12 Cells
Rats, Sprague-Dawley
Reg. No./Substance:
0/Culture Media, Conditioned

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