Document Detail


Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin.
MedLine Citation:
PMID:  11776054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the differentiation-inducing effect of hydroxycamptothecin (HCPT) on hepatoma Hep G2 cells. METHODS: 3-[4, 5-dimethylthial-2-yl]-3, 5-diphenyl-tetrazolinium bromide (MTT) colorimetric method was used for determining HepG2 cells viability. Alphafetoprotein (AFP) and albumin (ALB) levels were determined with Elisa Kits. RESULTS: The AFP secretion of HCPT-treated cells was reduced by 44.0%-49.2% while the ALB level was increased markedly. CONCLUSION: Hydroxycamptothecin can induce human hepatoma Hep G2 cells to differentiation.
Authors:
X Zhang; Y Zhou; B Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  113     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2002-01-03     Completed Date:  2002-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  712-3     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Shanghai Institute of Material Medical, Chinese Academy of Sciences, Shanghai 200031, China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Camptothecin / analogs & derivatives*,  pharmacology*
Carcinoma, Hepatocellular / pathology*
Cell Differentiation / drug effects*
Humans
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 67656-30-8/10-hydroxycamptothecin; 7689-03-4/Camptothecin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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