Document Detail

Differentiation of hidroacanthoma simplex from clonal seborrheic keratosis--an immunohistochemical study.
MedLine Citation:
PMID:  15166504     Owner:  NLM     Status:  MEDLINE    
Hidroacanthoma simplex (HS) is an uncommon poroid neoplasm confined within the epidermis. The clinical features of HS are not distinctive and histopathologically HS may be confused with clonal seborrheic keratosis (CSK) if cystic or ductal structure is not present. The purpose of our study was to differentiate HS from CSK by the immunohistochemical expressions of various cytokeratins, CEA, CD1a, and S-100 protein, as well as by the degrees of deposition of melanins and glycogen. Four cases of HS and seven cases of CSK were included in the research. In contrast with CSK, HS showed a very low density of Langerhans cells (19.9 +/- 7.7 versus 3.1 +/- 1.0 CD1a (+) cells/mm, P = 0.027) and sparse melanin deposition in the nests. However, HS could not be set apart from CSK by the expressions of cytokeratins. The nests of both HS and CSK showed very similar patterns of cytokeratin expression and seemed to be mainly composed of basaloid cells with focal differentiation toward epidermal suprabasal cells.
Han-Nan Liu; Yun-Ting Chang; Chih-Chiang Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  26     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-08-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-93     Citation Subset:  IM    
Department of Dermatology, Veterans General Hospital-Taipei and National Yang-Ming University, Taiwan, ROC.
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MeSH Terms
Acrospiroma / metabolism,  pathology*
Clone Cells
Dermatitis, Seborrheic / metabolism,  pathology*
Diagnosis, Differential
Glycogen / metabolism
Immunoenzyme Techniques
Keratins / metabolism
Langerhans Cells / metabolism,  pathology
Melanins / metabolism
Sweat Gland Neoplasms / metabolism,  pathology*
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Melanins; 0/Tumor Markers, Biological; 68238-35-7/Keratins; 9005-79-2/Glycogen

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