Document Detail

Differentiation of glioblastoma multiforme from astrocytomas by in vitro 1H MRS analysis of human brain tumors.
MedLine Citation:
PMID:  8694526     Owner:  NLM     Status:  MEDLINE    
In vitro high resolution 1H NMR spectroscopy allows non-invasive metabolic evaluation of specimens derived from surgically biopsied or resected brain tumors, with the aim of identifying potential markers of different malignancy grading, and improving diagnostic and therapeutic strategies. In the present study we evaluated 36 patients affected by different brain gliomas (7 well differentiated astrocytomas, 7 anaplastic astrocytomas, 16 glioblastomas, 6 oligodendrogliomas). These analyses allowed discrimination between well differentiated and anaplastic astrocytomas (AII + AA) and glioblastoma multiforme (GM) samples on the basis of the ratio between the integrated choline-containing resonance (b"Cho") and the creatine peaks (creatine (Cr) + Phosphocreatine (PCr)). While no definite difference was found between AII and AA, significantly higher values were observed for this ratio in GM. Other signals, derived from different metabolites, such as Glycine (Gly) and N-acetyl-aspartate (NAA), may also assume relevance in differential tumor diagnosis. In this study an increased [Gly]/[Cr + PCr] ratio was observed in GM with respect to AII and AA. The NAA levels observed in our tumor specimens may be explained on the basis of tumor cell infiltration into brain adjacent tissue. Interesting, but inconclusive, are the data concerning oligodendrogliomas, which, also in well differentiated forms, exhibit increased levels of b"Cho"/(Cr + PCr) ratio. The present study confirms the role of MRS in the biochemical characterization of neoplastic brain tissue and its potential contribution to a better selection of multidisciplinary treatment strategies.
G Carpinelli; C M Carapella; L Palombi; L Raus; F Caroli; F Podo
Related Documents :
9359626 - Establishment of a murine model for metastasis of cytokine-producing tumor to the brain.
22989616 - Chemokine receptor trio: cxcr3, cxcr4 and cxcr7 crosstalk via cxcl11 and cxcl12.
25432176 - Pi3k/mtor dual inhibitor vs-5584 preferentially targets cancer stem cells.
1443046 - Differential permeability of the blood-brain barrier in experimental brain metastases p...
22821506 - Evaluation of selected ultrasonographic parameters and marker levels in the preoperativ...
9568086 - Apoptosis induced by heavy ion (carbon) irradiation of two human tumours with different...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  16     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1996-08-29     Completed Date:  1996-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1559-63     Citation Subset:  IM    
Department of Cell Biology, Istituto Superiore di Sanità, Roma, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Astrocytoma / metabolism*
Brain Neoplasms / metabolism*
Choline / metabolism
Diagnosis, Differential
Glioblastoma / metabolism*
Magnetic Resonance Spectroscopy
Phosphocreatine / metabolism
Reg. No./Substance:
62-49-7/Choline; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diagnostic potential for cancer via 1H magnetic resonance spectroscopy of colon tissue.
Next Document:  In vivo proton MR spectroscopy: the diagnostic possibilities of lipid resonances in brain tumors.