Document Detail

Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics.
MedLine Citation:
PMID:  22500836     Owner:  NLM     Status:  In-Data-Review    
Summary:  Development of germinal center (GC) B cells and follicular helper T (Tfh) cells requires the transcription factor B-cell lymphoma 6 (Bcl6). Expression of Bcl6 in B cells and helper T cells is regulated by complex signals including those generated through their antigen-specific interactions, which take place in various microenvironments depending on their activation/differentiation states. In the last several years, it has become possible to detect Bcl6 protein in individual B cells and T cells by intracellular staining with the newly developed antibodies or by using the reporter mice. Experiments using these reagents have started to clarify microanatomical location of early Bcl6 upregulation in B cells and T cells, and contributed to reveal the dispensability and indispensability of B cells in the early and late phase of Tfh differentiation. They also started to reveal the diversity, plasticity, and/or instability of Tfh cells. We summarize the recent findings made by tracking Bcl6 expression together with the updated knowledge about dynamics of antigen-engaged B cells and helper T cells and discuss them in relation to possible signaling requirements for the development of GC B cells and Tfh cells.
Takaharu Okada; Saya Moriyama; Masahiro Kitano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunological reviews     Volume:  247     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  120-32     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Research Unit for Immunodynamics, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan. Laboratory for Lymphocyte Differentiation, RIKEN, Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
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