| Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 19323955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Autoreactive T cells play a major role in the pathogenesis of type 1 diabetes mellitus (T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing or delaying the disease onset. However, the T-cell response against insulin-producing beta cells is still poorly understood. T cells potentially able to recognize and destroy beta cells are present in most individuals, but only in a few do they differentiate into pathogenic effectors. Recent and novel findings in T-cell biology on the dynamics of T-cell activation and memory maintenance are shedding new light on the general mechanisms of the T-cell response. In this article, we discuss how new discoveries about T-cell differentiation, expansion, and homeostasis could help to clarify mechanisms of autoimmunity that lead to T1DM. |
| | |
Authors:
|
Paolo Monti; Anne-Kristin Heninger; Ezio Bonifacio |
Related Documents
:
|
9718985 - Ascorbic acid prevents beta-amyloid-induced intracellular calcium increase and cell dea... 19168505 - Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-pr... 2968845 - The s-100 beta protein in normal human peripheral blood is uniquely present within a di... 1469065 - Transforming growth factor-beta 1 induces expression of statin during differentiation o... 22585405 - Invariant natural killer t cells are not affected by lysosomal storage in patients with... 10196275 - A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory ... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current diabetes reports Volume: 9 ISSN: 1539-0829 ISO Abbreviation: Curr. Diab. Rep. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-27 Completed Date: 2009-07-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 113-8 Citation Subset: IM |
Affiliation:
|
Laboratory for Pre-clinical Approaches to Stem Cell Therapy, Center for Regenerative Therapies Dresden, Tatzberg 47/49, 01307 Dresden, Germany. Paolo.monti@crt-dresden.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoantigens / immunology* Cell Differentiation / immunology* Cell Proliferation Diabetes Mellitus, Type 1 / immunology*, pathology* Homeostasis / immunology* Humans T-Lymphocytes / cytology*, immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Autoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel antigens in type 1 diabetes: the importance of ZnT8.
Next Document: The contribution of hematopoietic stem cells to beta-cell replacement.