Document Detail

Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus.
MedLine Citation:
PMID:  19323955     Owner:  NLM     Status:  MEDLINE    
Autoreactive T cells play a major role in the pathogenesis of type 1 diabetes mellitus (T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing or delaying the disease onset. However, the T-cell response against insulin-producing beta cells is still poorly understood. T cells potentially able to recognize and destroy beta cells are present in most individuals, but only in a few do they differentiate into pathogenic effectors. Recent and novel findings in T-cell biology on the dynamics of T-cell activation and memory maintenance are shedding new light on the general mechanisms of the T-cell response. In this article, we discuss how new discoveries about T-cell differentiation, expansion, and homeostasis could help to clarify mechanisms of autoimmunity that lead to T1DM.
Paolo Monti; Anne-Kristin Heninger; Ezio Bonifacio
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current diabetes reports     Volume:  9     ISSN:  1539-0829     ISO Abbreviation:  Curr. Diab. Rep.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093791     Medline TA:  Curr Diab Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Laboratory for Pre-clinical Approaches to Stem Cell Therapy, Center for Regenerative Therapies Dresden, Tatzberg 47/49, 01307 Dresden, Germany.
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MeSH Terms
Autoantigens / immunology*
Cell Differentiation / immunology*
Cell Proliferation
Diabetes Mellitus, Type 1 / immunology*,  pathology*
Homeostasis / immunology*
T-Lymphocytes / cytology*,  immunology*
Reg. No./Substance:

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