Document Detail

Differentiation of exercise-induced metabolic responses during selective beta 1- and beta 2-antagonism.
MedLine Citation:
PMID:  3010028     Owner:  NLM     Status:  MEDLINE    
The effect of beta 1- or beta 2-antagonism on the plasma levels of glucose, lactate, triglycerides, and free fatty acids was studied in seventeen normal male volunteers. All subjects performed three graded and uninterrupted exercise tests until exhaustion. Prior to each exercise test they received in a randomized order during three consecutive days either placebo or a predominant beta 1-blocker (atenolol, 50 mg once per day) or a predominant beta 2-blocker (ICI 118,551, 20 mg t.i.d.), according to a double-blind cross-over study design. Atenolol increased the plasma level of glucose at rest but did not influence the rise in plasma glucose during exercise. ICI 118,551 did not change the resting plasma glucose level, but it prevented the exercise-induced rise in plasma glucose, observed during placebo. During beta 1-antagonism the plasma lactate concentration at rest and during or after exercise was not different from placebo. During beta 2-blockade the exercise-induced rise in plasma lactate tended to be suppressed, and during recovery the plasma lactate levels were significantly lower than during placebo. The serum triglycerides concentration at rest and exercise was not altered, either by beta 1- or by beta 2-antagonism. Atenolol and ICI 118,551 did not affect the serum level of free fatty acids at rest, but at moderate exercise the serum free fatty acids concentration was lower during beta 1-blockade than during placebo. Our results provide further evidence that beta 2-adrenergic receptors are involved in the regulation of the plasma levels of glucose and lactate during exercise.
P Hespel; P Lijnen; L Vanhees; R Fagard; R Fiocchi; E Moerman; A Amery
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  18     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-02     Completed Date:  1986-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM; S    
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MeSH Terms
Atenolol / pharmacology
Blood Glucose / metabolism*
Blood Pressure / drug effects
Fatty Acids, Nonesterified / blood
Glycogen / metabolism
Heart Rate / drug effects
Lactates / blood*
Lactic Acid
Lipolysis / drug effects
Muscles / metabolism
Oxygen Consumption / drug effects
Physical Exertion*
Propanolamines / pharmacology
Receptors, Adrenergic, beta / drug effects,  metabolism*
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Propanolamines; 0/Receptors, Adrenergic, beta; 0/Triglycerides; 29122-68-7/Atenolol; 50-21-5/Lactic Acid; 72795-19-8/ICI 118551; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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