Document Detail

Differentiation of cows' milk intolerance and gastro-oesophageal reflux.
MedLine Citation:
PMID:  8554363     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to compare a non-invasive test of small bowel permeability with a more invasive approach involving endoscopy, mucosal biopsy, and oesophageal pH monitoring for rapidly differentiating gastro-oesophageal reflux (GOR) and cows' milk intolerance in 25 infants with persistent vomiting. Each subject underwent a cellobiose/mannitol permeability study, upper gastrointestinal endoscopy with oesophageal and small bowel biopsies, and a 24 hour pH study. Reflux disease and/or cows' milk intolerance was responsible for vomiting in 24 (96%) of the subjects. Sixteen (64%) of the infants had GOR alone, four (16%) had GOR and cows' milk intolerance, and four (16%) had cows' milk intolerance alone. Morphometric analysis of small bowel biopsies was abnormal in 19% of the patients with GOR alone and in 67% with cows' milk intolerance with or without GOR. The permeability test was abnormal in only 6% of the patients with GOR but in 100% with GOR and cows' milk intolerance and in 100% with cows' milk intolerance alone. The non-invasive permeability study aimed at rapid determination of cows' milk intolerance should pre-empt a more invasive approach in the evaluation of infants with persistent vomiting.
A Staiano; R Troncone; D Simeone; M Mayer; E Finelli; A Cella; S Auricchio
Related Documents :
1395563 - The sensitizing capacity of the antioxidants propyl, octyl, and dodecyl gallate and som...
16864863 - Induction of precocious puberty in heifers ii: advanced ovarian follicular development.
10149693 - Infant ventilation and oxygenation by basic life support providers: comparison of methods.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  73     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-02-20     Completed Date:  1996-02-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  439-42     Citation Subset:  AIM; IM    
Department of Paediatrics, University Federico II, Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cellobiose / pharmacokinetics
Diagnosis, Differential
Endoscopy, Digestive System
Gastroesophageal Reflux / diagnosis*
Intestines / metabolism
Mannitol / pharmacokinetics
Milk Hypersensitivity / diagnosis*
Sensitivity and Specificity
Reg. No./Substance:
16462-44-5/Cellobiose; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Putting it on tape: audio taped assessment summaries for parents.
Next Document:  Factors affecting rectal temperature in infancy.