| Differentiation of cows' milk intolerance and gastro-oesophageal reflux. | |
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MedLine Citation:
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PMID: 8554363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare a non-invasive test of small bowel permeability with a more invasive approach involving endoscopy, mucosal biopsy, and oesophageal pH monitoring for rapidly differentiating gastro-oesophageal reflux (GOR) and cows' milk intolerance in 25 infants with persistent vomiting. Each subject underwent a cellobiose/mannitol permeability study, upper gastrointestinal endoscopy with oesophageal and small bowel biopsies, and a 24 hour pH study. Reflux disease and/or cows' milk intolerance was responsible for vomiting in 24 (96%) of the subjects. Sixteen (64%) of the infants had GOR alone, four (16%) had GOR and cows' milk intolerance, and four (16%) had cows' milk intolerance alone. Morphometric analysis of small bowel biopsies was abnormal in 19% of the patients with GOR alone and in 67% with cows' milk intolerance with or without GOR. The permeability test was abnormal in only 6% of the patients with GOR but in 100% with GOR and cows' milk intolerance and in 100% with cows' milk intolerance alone. The non-invasive permeability study aimed at rapid determination of cows' milk intolerance should pre-empt a more invasive approach in the evaluation of infants with persistent vomiting. |
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Authors:
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A Staiano; R Troncone; D Simeone; M Mayer; E Finelli; A Cella; S Auricchio |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Archives of disease in childhood Volume: 73 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-02-20 Completed Date: 1996-02-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 439-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatrics, University Federico II, Naples, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cellobiose
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pharmacokinetics Diagnosis, Differential Endoscopy, Digestive System Female Gastroesophageal Reflux / diagnosis* Humans Infant Intestines / metabolism Male Mannitol / pharmacokinetics Milk Hypersensitivity / diagnosis* Permeability Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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16462-44-5/Cellobiose; 69-65-8/Mannitol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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