Document Detail


Differentiation of cows' milk intolerance and gastro-oesophageal reflux.
MedLine Citation:
PMID:  8554363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to compare a non-invasive test of small bowel permeability with a more invasive approach involving endoscopy, mucosal biopsy, and oesophageal pH monitoring for rapidly differentiating gastro-oesophageal reflux (GOR) and cows' milk intolerance in 25 infants with persistent vomiting. Each subject underwent a cellobiose/mannitol permeability study, upper gastrointestinal endoscopy with oesophageal and small bowel biopsies, and a 24 hour pH study. Reflux disease and/or cows' milk intolerance was responsible for vomiting in 24 (96%) of the subjects. Sixteen (64%) of the infants had GOR alone, four (16%) had GOR and cows' milk intolerance, and four (16%) had cows' milk intolerance alone. Morphometric analysis of small bowel biopsies was abnormal in 19% of the patients with GOR alone and in 67% with cows' milk intolerance with or without GOR. The permeability test was abnormal in only 6% of the patients with GOR but in 100% with GOR and cows' milk intolerance and in 100% with cows' milk intolerance alone. The non-invasive permeability study aimed at rapid determination of cows' milk intolerance should pre-empt a more invasive approach in the evaluation of infants with persistent vomiting.
Authors:
A Staiano; R Troncone; D Simeone; M Mayer; E Finelli; A Cella; S Auricchio
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  73     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-02-20     Completed Date:  1996-02-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  439-42     Citation Subset:  AIM; IM    
Affiliation:
Department of Paediatrics, University Federico II, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cellobiose / pharmacokinetics
Diagnosis, Differential
Endoscopy, Digestive System
Female
Gastroesophageal Reflux / diagnosis*
Humans
Infant
Intestines / metabolism
Male
Mannitol / pharmacokinetics
Milk Hypersensitivity / diagnosis*
Permeability
Sensitivity and Specificity
Chemical
Reg. No./Substance:
16462-44-5/Cellobiose; 69-65-8/Mannitol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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