Document Detail

Differentiation of columnar epithelia: the hensin pathway.
MedLine Citation:
PMID:  17130293     Owner:  NLM     Status:  MEDLINE    
Epithelia, the most common variety of cells in complex organisms exist in many shapes. They are sheets of polarized cells that separate two compartments and selectively transport materials from one to the other. After acquiring these general characteristics, they differentiate to become specialized types such as squamous columnar or transitional epithelia. High density seeding converts a kidney-derived cell line from flat ;generic' epithelial cells to columnar cells. The cells acquire all the characteristics of differentiated columnar cells, including microvilli, and the capacity for apical endocytosis. The high seeding density induces the deposition of a new protein termed hensin and polymerization of hensin is the crucial event that dictates changes in epithelial phenotype. Hensin is widely expressed in most epithelia. Its deletion in mice leads to embryonic lethality at the time of generation of the first columnar epithelium, the visceral endoderm. Moreover many human cancers have deletions in the hensin gene, which indicates that it is a tumor suppressor.
Soundarapandian Vijayakumar; Jiro Takito; XiaoBo Gao; George J Schwartz; Qais Al-Awqati
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  119     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2007-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  4797-801     Citation Subset:  IM    
Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 W 168th St, New York, NY 10032, USA.
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MeSH Terms
Cell Differentiation / physiology*
Embryonic Development / genetics
Epithelial Cells / cytology*
Kidney / cytology
Models, Biological
Mucins / genetics,  metabolism,  physiology*
Neoplasms / genetics
Signal Transduction
Reg. No./Substance:
0/Dmbt1 protein, mouse; 0/Mucins; 0/Polymers

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