Document Detail

Differentiation between extrahepatic and intrahepatic cholestasis by discriminant analysis.
MedLine Citation:
PMID:  1976325     Owner:  NLM     Status:  MEDLINE    
Discriminant analysis was used to differentiate between extrahepatic biliary atresia and intrahepatic cholestasis. Among the ten laboratory variables tested, three (gamma-glutamyl transpeptidase, alkaline phosphatase and total serum bilirubin) were useful in the differential diagnosis. gamma-Glutamyl transpeptidase contributed most to the discrimination (85%). From a population study of 28 babies with extrahepatic biliary atresia and 24 infants with intrahepatic cholestasis, the procedure achieved a diagnostic accuracy and specificity of 92.9% and an efficiency of 92.3%. The jackknife procedure has also confirmed that the mathematical model was robust for discriminant analysis and therefore it may be valid for screening infants with cholestasis for early surgical intervention. Discriminant analysis is a useful adjunct for differentiation between intrahepatic cholestasis and extrahepatic biliary atresia.
K P Fung; S P Lau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  26     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-10-31     Completed Date:  1990-10-31     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  132-5     Citation Subset:  IM    
Department of Paediatrics, National University Hospital, National University of Singapore, Hong Kong.
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MeSH Terms
Alkaline Phosphatase / blood
Biliary Atresia / complications,  diagnosis
Bilirubin / blood
Cholestasis, Extrahepatic / blood,  diagnosis*,  etiology
Cholestasis, Intrahepatic / blood,  diagnosis*
Diagnosis, Differential
Discriminant Analysis
Liver Function Tests
gamma-Glutamyltransferase / blood
Reg. No./Substance:
635-65-4/Bilirubin; EC; EC Phosphatase

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