Document Detail


Differentiation between acutely ischemic myocardium and zones of completed infarction in dogs on the basis of frequency-dependent backscatter.
MedLine Citation:
PMID:  2663954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The goal of this work was to determine whether the frequency dependence of apparent backscatter coefficient (not corrected for attenuation within the myocardium) could differentiate completed, remote infarction from acute myocardial injury in vivo. Myocardial infarcts were produced in six dogs by coronary artery occlusion. One to 12 months later, acute ischemic injury was induced in each dog by ligation of a coronary artery that supplied a region of myocardium adjacent to the established infarct. Infarct, ischemic, and normal regions were interrogated with a 5-MHz, circular, 0.5-in. diam, broadband, focused, piezoelectric transducer mounted in a water-filled stand-off device placed against the exposed, beating heart. Apparent backscatter coefficients were measured over the range of frequencies from 3-7 MHz. The frequency dependence was obtained from the slope of log apparent backscatter coefficient versus log frequency. No significant difference in frequency dependence was found between normal and acutely ischemic myocardium for periods of up to 2 h of ischemia. In contrast, frequency dependence in regions of remote infarct (1.8 +/- 0.1, mean +/- standard error) was significantly lower than that in acutely ischemic or nonischemic regions (2.3 +/- 0.1) (p less than 0.01). These results suggest that remote myocardial infarction can be differentiated from acutely injured but still potentially salvageable myocardium in vivo on the basis of the frequency dependence of backscatter.
Authors:
K A Wear; M R Milunski; S A Wickline; J E Perez; B E Sobel; J G Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  85     ISSN:  0001-4966     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-08-21     Completed Date:  1989-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2634-41     Citation Subset:  IM    
Affiliation:
Department of Physics, Washington University, St. Louis, Missouri 63130.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Disease / diagnosis*,  physiopathology
Dogs
Ultrasonography*
Grant Support
ID/Acronym/Agency:
HL17646/HL/NHLBI NIH HHS; HL40302/HL/NHLBI NIH HHS

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