Document Detail

Differentiation of T-cell precursors in nude mice demonstrated by immunofluorescence of T-cell membrane markers.
Jump to Full Text
MedLine Citation:
PMID:  4583069     Owner:  NLM     Status:  MEDLINE    
When the thymus from an AKR mouse (TL(-), theta-AKR) is grafted to a BALB/c-nu/nu mouse (TL2, theta-C3H), the grafted thymus is rapidly repopulated by host lymphocytes, i.e., lymphocytes having the TL2 and theta-C3H T-lymphocyte membrane antigen markers. theta-C3H lymphocytes also appear rapidly in the spleen and lymph nodes. After a few weeks, BALB/c nude mice grafted with AKR thymus and normal BALB/c mice could not be distinguished on the basis of the number of TL-positive thymocytes or theta-C3H-positive lymphocytes in thymus, spleen, or lymph nodes. These experiments give a definitive proof of the existence of precursor cells for the T compartment of the lymphoid system in the nude mouse. They strongly suggest the involvement of host-derived T cells in the recovery of some T-cell functions by nude mice grafted with allogeneic thymuses.
F Loor; B Kindred
Related Documents :
9099789 - Mechanisms of selection and differentiation in germinal centers.
2645579 - Sequence of the lyb-2 b-cell differentiation antigen defines a gene superfamily of rece...
19652369 - Nitric oxide modulates osteoblastic differentiation with heme oxygenase-1 via the mitog...
7248949 - Differentiation of fibroblast-like cells into macrophages.
21332449 - Effect of carbon nanotube coating of aligned nanofibrous polymer scaffolds on the neuri...
8835319 - Altered distribution of the nuclear receptor rar beta accompanies proliferation and dif...
1329529 - Rabbit esophageal cell cytoplasmic ph regulation: role of na(+)-h+ antiport and na(+)-d...
20155159 - Multireflection raman cell: a design.
6823509 - Characterization and radiation response of a heat-resistant variant of v79 cells.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  138     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1973 Nov 
Date Detail:
Created Date:  1973-12-15     Completed Date:  1973-12-15     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1044-55     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens / analysis*,  isolation & purification
Binding Sites, Antibody
Cell Membrane / immunology*
Fluorescent Antibody Technique
Mice, Inbred AKR
Mice, Inbred BALB C
T-Lymphocytes / immunology*
Thymus Gland / immunology*,  transplantation
Transplantation, Homologous
Reg. No./Substance:
0/Antigens; 0/Binding Sites, Antibody

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
Download PDF
Copyright © 1973 by The Rockefeller University Press
Received Day: 12 Month: 7 Year: 1973
Print publication date: Day: 31 Month: 10 Year: 1973
Volume: 138 Issue: 5
First Page: 1044 Last Page: 1055
ID: 2139440
PubMed Id: 4583069

F. Loor
B. Kindred
From the Basel Institute for Immunology, CH-4058 Basel, Switzerland

Article Categories:
  • Article

Previous Document:  Prospects of chemosterilant and genetic control of rodents.
Next Document:  Requirement for alpha-L-fucose on the macrophage membrane receptor for MIF.