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Differentiation of T-cell precursors in nude mice demonstrated by immunofluorescence of T-cell membrane markers.
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MedLine Citation:
PMID:  4583069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When the thymus from an AKR mouse (TL(-), theta-AKR) is grafted to a BALB/c-nu/nu mouse (TL2, theta-C3H), the grafted thymus is rapidly repopulated by host lymphocytes, i.e., lymphocytes having the TL2 and theta-C3H T-lymphocyte membrane antigen markers. theta-C3H lymphocytes also appear rapidly in the spleen and lymph nodes. After a few weeks, BALB/c nude mice grafted with AKR thymus and normal BALB/c mice could not be distinguished on the basis of the number of TL-positive thymocytes or theta-C3H-positive lymphocytes in thymus, spleen, or lymph nodes. These experiments give a definitive proof of the existence of precursor cells for the T compartment of the lymphoid system in the nude mouse. They strongly suggest the involvement of host-derived T cells in the recovery of some T-cell functions by nude mice grafted with allogeneic thymuses.
Authors:
F Loor; B Kindred
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  138     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1973 Nov 
Date Detail:
Created Date:  1973-12-15     Completed Date:  1973-12-15     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1044-55     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens / analysis*,  isolation & purification
Binding Sites, Antibody
Cell Membrane / immunology*
Fluorescent Antibody Technique
Mice
Mice, Inbred AKR
Mice, Inbred BALB C
T-Lymphocytes / immunology*
Thymus Gland / immunology*,  transplantation
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Antigens; 0/Binding Sites, Antibody
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1973 by The Rockefeller University Press
Received Day: 12 Month: 7 Year: 1973
Print publication date: Day: 31 Month: 10 Year: 1973
Volume: 138 Issue: 5
First Page: 1044 Last Page: 1055
ID: 2139440
PubMed Id: 4583069

DIFFERENTIATION OF T-CELL PRECURSORS IN NUDE MICE DEMONSTRATED BY IMMUNOFLUORESCENCE OF T-CELL MEMBRANE MARKERS
F. Loor
B. Kindred
From the Basel Institute for Immunology, CH-4058 Basel, Switzerland


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