| Differentiation of T-cell precursors in nude mice demonstrated by immunofluorescence of T-cell membrane markers. | |
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MedLine Citation:
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PMID: 4583069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When the thymus from an AKR mouse (TL(-), theta-AKR) is grafted to a BALB/c-nu/nu mouse (TL2, theta-C3H), the grafted thymus is rapidly repopulated by host lymphocytes, i.e., lymphocytes having the TL2 and theta-C3H T-lymphocyte membrane antigen markers. theta-C3H lymphocytes also appear rapidly in the spleen and lymph nodes. After a few weeks, BALB/c nude mice grafted with AKR thymus and normal BALB/c mice could not be distinguished on the basis of the number of TL-positive thymocytes or theta-C3H-positive lymphocytes in thymus, spleen, or lymph nodes. These experiments give a definitive proof of the existence of precursor cells for the T compartment of the lymphoid system in the nude mouse. They strongly suggest the involvement of host-derived T cells in the recovery of some T-cell functions by nude mice grafted with allogeneic thymuses. |
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Authors:
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F Loor; B Kindred |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 138 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1973 Nov |
Date Detail:
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Created Date: 1973-12-15 Completed Date: 1973-12-15 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1044-55 Citation Subset: AIM; IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens / analysis*, isolation & purification Binding Sites, Antibody Cell Membrane / immunology* Fluorescent Antibody Technique Mice Mice, Inbred AKR Mice, Inbred BALB C T-Lymphocytes / immunology* Thymus Gland / immunology*, transplantation Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Binding Sites, Antibody |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1973 by The Rockefeller University Press Received Day: 12 Month: 7 Year: 1973 Print publication date: Day: 31 Month: 10 Year: 1973 Volume: 138 Issue: 5 First Page: 1044 Last Page: 1055 ID: 2139440 PubMed Id: 4583069 |
| DIFFERENTIATION OF T-CELL PRECURSORS IN NUDE MICE DEMONSTRATED BY IMMUNOFLUORESCENCE OF T-CELL MEMBRANE MARKERS | |
| F. Loor | |
| B. Kindred | |
| From the Basel Institute for Immunology, CH-4058 Basel, Switzerland |
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