Document Detail


Differentiation of prostatitis and prostate cancer by using diffusion-weighted MR imaging and MR-guided biopsy at 3 T.
MedLine Citation:
PMID:  23329653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine if prostatitis and prostate cancer (PCa) can be distinguished by using apparent diffusion coefficients (ADCs) on magnetic resonance (MR) images, with specimens obtained at MR-guided biopsy as the standard of reference.
MATERIALS AND METHODS: The need for institutional review board approval and informed consent was waived. MR-guided biopsies were performed in 130 consecutive patients with cancer-suspicious regions (CSRs) on multiparametric MR images obtained at 3 T. In this retrospective study, 88 patients met the inclusion criteria. During the biopsy procedure, an axial diffusion-weighted sequence was performed and ADC maps were generated (repetition time msec/echo time msec, 2000/67; section thickness, 4 mm; in-plane resolution, 1.8 × 1.8 mm; and b values of 0, 100, 500, and 800 sec/mm(2)). Subsequently, a confirmation image with the needle left in situ was acquired and projected on the ADC map. The corresponding ADCs at the biopsy location were compared with the histopathologic outcomes of the biopsy specimens. Linear mixed-model regression analyses were used to test for ADC differences between the histopathologic groups.
RESULTS: The study included 116 biopsy specimens. Median ADCs of normal prostate tissue, prostatitis, low-grade PCa (Gleason grade components 2 or 3), and high-grade PCa (Gleason grade components 4 or 5) were 1.22 × 10(-3) mm(2)/sec (standard deviation, ± 0.21), 1.08 × 10(-3) mm(2)/sec (± 0.18), 0.88 × 10(-3) mm(2)/sec (± 0.15), and 0.88 × 10(-3) mm(2)/sec (± 0.13), respectively. Although the median ADCs of biopsy specimens with prostatitis were significantly higher compared with low- and high-grade PCa (P < .001), there is a considerable overlap between the tissue types.
CONCLUSION: Diffusion-weighted imaging is a noninvasive technique that shows differences between prostatitis and PCa in both the peripheral zone and central gland, although its usability in clinical practice is limited as a result of significant overlap in ADCs.
Authors:
Klaas N A Nagel; Martijn G Schouten; Thomas Hambrock; Geert J S Litjens; Caroline M A Hoeks; Bennie ten Haken; Jelle O Barentsz; Jurgen J Fütterer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Radiology     Volume:  267     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-25     Completed Date:  2013-05-16     Revised Date:  2014-01-31    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-72     Citation Subset:  AIM; IM    
Copyright Information:
RSNA, 2013
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MeSH Terms
Descriptor/Qualifier:
Aged
Biopsy
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging*
Humans
Image Interpretation, Computer-Assisted
Linear Models
Magnetic Resonance Imaging, Interventional*
Male
Prostatic Neoplasms / diagnosis*,  pathology
Prostatitis / diagnosis*,  pathology
Retrospective Studies
Statistics, Nonparametric
Comments/Corrections
Comment In:
Rofo. 2013 Oct;185(10):926
Rofo. 2013 Sep;184(10):926   [PMID:  24218684 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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