Document Detail

Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes.
MedLine Citation:
PMID:  2122465     Owner:  NLM     Status:  MEDLINE    
The activated c-Ha-ras oncogene induced AP1-site DNA-binding activity in F9 cells. This induction appeared to be due, at least in part, to the induction of c-jun transcription. Both activated c-Ha-ras and c-jun induced the differentiation of F9 cells to endoderm-like cells. Thus, AP1 appears to play a key role in the initial stage of F9 cell differentiation.
Y Yamaguchi-Iwai; M Satake; Y Murakami; M Sakai; M Muramatsu; Y Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  87     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8670-4     Citation Subset:  IM    
Department of Viral Oncology, Kyoto University, Japan.
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MeSH Terms
Base Sequence
Blotting, Northern
Cell Differentiation*
DNA-Binding Proteins / genetics*
Genes, ras*
Molecular Sequence Data
Protein-Tyrosine Kinases / genetics
Proto-Oncogene Proteins c-jun
RNA, Neoplasm / genetics,  isolation & purification
Transcription Factors / genetics*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Neoplasm; 0/Transcription Factors; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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