Document Detail


Differentiation of Clostridium difficile toxin from Clostridium botulinum toxin by the mouse lethality test.
MedLine Citation:
PMID:  6824325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mouse lethality test is the most sensitive method for confirming the diagnosis of infant botulism. Both Clostridium difficile and Clostridium botulinum produce heat-labile toxins which are lethal for mice and can be found in the feces of infants. These two toxins can be distinguished from one another in this assay when both are present in the same fecal specimen because they appear to be immunologically distinct toxins.
Authors:
P H Gilligan; L Brown; R E Berman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  45     ISSN:  0099-2240     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Toxins / analysis,  classification*,  immunology
Biological Assay
Botulinum Toxins / analysis,  classification*,  immunology
Clostridium / analysis*
Cross Reactions
Feces / analysis*
Humans
Infant
Mice
Neutralization Tests
Chemical
Reg. No./Substance:
0/Bacterial Toxins; 0/Botulinum Toxins
Comments/Corrections

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