| Differentiation of African components of ancestry to stratify groups in a case-control study of a Brazilian urban population. | |
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MedLine Citation:
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PMID: 22288895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Balancing the subject composition of case and control groups to create homogenous ancestries between each group is essential for medical association studies. METHODS: We explored the applicability of single-tube 34-plex ancestry informative markers (AIM) single nucleotide polymorphisms (SNPs) to estimate the African Component of Ancestry (ACA) to design a future case-control association study of a Brazilian urban sample. RESULTS: One hundred eighty individuals (107 case group; 73 control group) self-described as white, brown-intermediate or black were selected. The proportions of the relative contribution of a variable number of ancestral population components were similar between case and control groups. Moreover, the case and control groups demonstrated similar distributions for ACA <0.25 and >0.50 categories. Notably a high number of outlier values (23 samples) were observed among individuals with ACA <0.25. These individuals presented a high probability of Native American and East Asian ancestral components; however, no individuals originally giving these self-described ancestries were observed in this study. CONCLUSIONS: The strategy proposed for the assessment of ancestry and adjustment of case and control groups for an association study is an important step for the proper construction of the study, particularly when subjects are taken from a complex urban population. This can be achieved using a straight forward multiplexed AIM-SNPs assay of highly discriminatory ancestry markers. |
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Authors:
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Vivian N Silbiger; Mario H Hirata; Andre D Luchessi; Fabiana D V Genvigir; Alvaro Cerda; Alice C Rodrigues; Maria A V Willrich; Simone S Arazi; Egidio L Dorea; Marcia M S Bernik; Andre A Faludi; Marcelo C Bertolami; Carla Santos; Angel Carracedo; Antonio Salas; Ana Freire; Maria Victoria Lareu; Christopher Phillips; Liliana Porras-Hurtado; Manuel Fondevila; Rosario D C Hirata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-30 |
Journal Detail:
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Title: Genetic testing and molecular biomarkers Volume: 16 ISSN: 1945-0257 ISO Abbreviation: Genet Test Mol Biomarkers Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-21 Completed Date: 2012-10-22 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101494210 Medline TA: Genet Test Mol Biomarkers Country: United States |
Other Details:
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Languages: eng Pagination: 524-30 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, Brazil. viviansilbiger@usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group
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ethnology,
genetics* Asian Continental Ancestry Group / ethnology, genetics Brazil / ethnology Case-Control Studies* European Continental Ancestry Group / ethnology, genetics Female Humans Hypercholesterolemia / genetics* Indians, South American / ethnology*, genetics Male Polymorphism, Single Nucleotide* Population Groups / ethnology, genetics Urban Population* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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