| Differentiating hippocampal subregions by means of quantitative magnetization transfer and relaxometry: preliminary results. | |
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MedLine Citation:
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PMID: 15528109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hippocampal formation (HF) of healthy control subjects and schizophrenic patients was examined using an MRI experiment that implements sequences for relaxometry and magnetization transfer (MT) quantification. In addition to the semi-quantitative magnetization transfer ratio (MTR), all of the observable properties of the binary spin bath model were included. The study demonstrates that, in contrast to the MTR, quantitative MT parameters (especially the T2 relaxation time of restricted protons, T2b) are capable to differentiate functionally significant subregions within the HF. The MT methodology appears to be a promising new tool for the differential microstructural evaluation of the HF in neuropsychiatric disorders accompanied by memory disturbances. |
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Authors:
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Claus Kiefer; Johannes Slotboom; Caroline Buri; Jan Gralla; Luca Remonda; Thomas Dierks; Werner K Strik; Gerhard Schroth; Peter Kalus |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: NeuroImage Volume: 23 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-05 Completed Date: 2005-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 1093-9 Citation Subset: IM |
Affiliation:
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Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern (Inselspital), Freiburgstrasse 4, CH-3010 Bern, Switzerland. claus.kiefer@insel.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Functional Laterality / physiology Hippocampus / physiopathology* Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Male Memory Disorders / physiopathology Schizophrenia / physiopathology* Software |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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