Document Detail


Differentiated thyroid cancer in a Swedish county--long-term results and quality of life.
MedLine Citation:
PMID:  20092427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is still no complete agreement about the proper treatment of differentiated thyroid cancer (DTC). MATERIAL AND METHODS: All patients (n=130) with DTC in a defined population, treated with surgery between 1985 and 1999, were carefully followed up (median 13.1 years). Fifty three were operated with subtotal and 77 with total thyroidectomy. Twenty seven percent of the patients in the subtotal group and 56% of those in the total thyroidectomy group had postoperative radioiodine ablation. Thirty nine patients had papillary cancers incidentally detected during surgery for benign disorders (median size 7 (1-30) mm). Living patients answered the Swedish version of the SF-36 health survey. RESULTS: Eleven of 106 patients considered tumour-free after primary surgery developed recurrences during follow-up. Fifteen patients (12%) died from DTC but only one within stage I-II (1.2%). No patient below 50 years of age at diagnosis died from DTC. Only three of 29 patients with isolated loco-regional spreading of their disease at the time of diagnosis have died from thyroid cancer. There was no statistically significant difference in the 10 year cancer-specific survival rate between those operated with subtotal or total thyroidectomy--irrespective of stage. Survival rate was significantly better for papillary than for follicular cancer. Mental and physical quality of life among patients treated for DTC were similar to the healthy Swedish population. CONCLUSIONS: Patients with DTC stage I-II (according to TNM) or low-risk (according to AMES) have an excellent prognosis. Treatment as well as follow-up should not be exaggerated.
Authors:
Rebecka R Malterling; Roland E Andersson; Sture Falkmer; Ursula Falkmer; Eva Nil?hn; Johannes J?rhult
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  49     ISSN:  1651-226X     ISO Abbreviation:  Acta Oncol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  454-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, Ryhov Hospital, J?nk?ping, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Follicular / epidemiology,  surgery
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma / epidemiology*,  pathology,  radiotherapy,  surgery*
Carcinoma, Papillary / epidemiology,  surgery
Disease-Free Survival
Female
Humans
Iodine Radioisotopes / therapeutic use*
Male
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Prognosis
Quality of Life*
Radiotherapy, Adjuvant
Registries
Sample Size
Sweden / epidemiology
Thyroid Neoplasms / epidemiology*,  pathology,  radiotherapy,  surgery*
Thyroidectomy / methods*
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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