| Differentiated (simplex) vulvar intraepithelial neoplasia: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 21522046 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Differentiated (simplex) vulvar intraepithelial neoplasia (VIN) is an uncommon variant of VIN characterized by highly differentiated morphology, making it a potential diagnostic pitfall. It may arise in the background of lichen sclerosus, and unlike most VIN, is not causally associated with human papilloma virus infection. It occurs in an older demographic and is thought to be the precursor of aggressive, invasive vulvar squamous cell carcinoma. For this reason, the timely and accurate diagnosis of this unusual lesion is crucial. The clinical and histologic features of a case of a 70-year-old woman with newly diagnosed differentiated (simplex) VIN arising in a background of long-standing lichen sclerosus is reported, and the historic aspects, current terminology, and diagnostic criteria of differentiated (simplex) VIN are reviewed. |
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Authors:
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Janis M Taube; Joanna Badger; Christina S Kong; Soheil S Dadras |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 33 ISSN: 1533-0311 ISO Abbreviation: Am J Dermatopathol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: e27-30 Citation Subset: IM |
Affiliation:
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From *The Johns Hopkins University School of Medicine, Departments of Dermatology and Pathology, Baltimore, MD; †Stanford University School of Medicine, Department of Dermatology, Stanford, CA; ‡Stanford University School of Medicine, Department of Pathology, Stanford, CA; and §University of Connecticut, Departments of Dermatology and Genetics/Developmental Biology, Farmington, CT. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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