| Differentiated neuroblastoma cells provide a highly efficient model for studies of productive varicella-zoster virus infection of neuronal cells. | |
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MedLine Citation:
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PMID: 21632750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV infection of neuronal cells. We show that differentiation of SH-SY5Y neuroblastoma cells yields a homogenous population of neuron-like cells that are permissive to the full VZV replicative cycle. These cells supported productive infection by both laboratory and clinical VZV isolates, including the live varicella vaccine. This model may enable rapid identification of genetic determinants facilitating VZV neurotropism. |
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Authors:
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Jenna Christensen; Megan Steain; Barry Slobedman; Allison Abendroth |
Publication Detail:
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Type: Journal Article Date: 2011-06-01 |
Journal Detail:
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Title: Journal of virology Volume: 85 ISSN: 1098-5514 ISO Abbreviation: J. Virol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-21 Completed Date: 2011-10-04 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 8436-42 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases and Immunology, University of Sydney, Sydney 2006, New South Wales, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Culture Techniques Cell Line, Tumor Ganglia, Sensory / virology Herpesvirus 3, Human / growth & development, physiology* Humans Neuroblastoma / virology* Neurons / virology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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