Document Detail

Differentiated neuroblastoma cells provide a highly efficient model for studies of productive varicella-zoster virus infection of neuronal cells.
MedLine Citation:
PMID:  21632750     Owner:  NLM     Status:  MEDLINE    
Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV infection of neuronal cells. We show that differentiation of SH-SY5Y neuroblastoma cells yields a homogenous population of neuron-like cells that are permissive to the full VZV replicative cycle. These cells supported productive infection by both laboratory and clinical VZV isolates, including the live varicella vaccine. This model may enable rapid identification of genetic determinants facilitating VZV neurotropism.
Jenna Christensen; Megan Steain; Barry Slobedman; Allison Abendroth
Publication Detail:
Type:  Journal Article     Date:  2011-06-01
Journal Detail:
Title:  Journal of virology     Volume:  85     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-21     Completed Date:  2011-10-04     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8436-42     Citation Subset:  IM    
Department of Infectious Diseases and Immunology, University of Sydney, Sydney 2006, New South Wales, Australia.
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MeSH Terms
Cell Culture Techniques
Cell Line, Tumor
Ganglia, Sensory / virology
Herpesvirus 3, Human / growth & development,  physiology*
Neuroblastoma / virology*
Neurons / virology*

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