Document Detail


Differentially regulated gene expression associated with hepatitis C virus clearance.
MedLine Citation:
PMID:  23152368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human chronic hepatitis C virus (HCV) infections pose a significant public health threat, necessitating the development of novel treatments and vaccines. HCV infections range from spontaneous resolution to end-stage liver disease. Approximately 10-30% of HCV infections undergo spontaneous resolution independent of treatment by yet-to-be-defined mechanisms. These individuals test positive for anti-HCV antibodies in the absence of detectable viral serum RNA. To identify genes associated with HCV clearance, this study compared gene expression profiles between current drug users chronically infected with HCV and drug users who cleared their HCV infection. This analysis identified 91 differentially regulated (up- or downregulated by twofold or more) genes potentially associated with HCV clearance. The majority of genes identified were associated with immune function, with the remaining genes categorized either as cancer related or 'other'. Identification of factors and pathways that may influence virus clearance will be essential to the development of novel treatment strategies.
Authors:
Carolyn Z Grimes; Lu-Yu Hwang; Peng Wei; Dimpy P Shah; Kelly A Volcik; Eric L Brown
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-11-14
Journal Detail:
Title:  The Journal of general virology     Volume:  94     ISSN:  1465-2099     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-04-17     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  England    
Other Details:
Languages:  eng     Pagination:  534-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Viral / blood
Antiviral Agents / therapeutic use
Case-Control Studies
Female
Gene Expression Regulation / immunology*
Hepacivirus / physiology*
Hepatitis B / prevention & control
Hepatitis B Vaccines / immunology
Hepatitis C / drug therapy,  virology*
Humans
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
1R01DA017505/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Antiviral Agents; 0/Hepatitis B Vaccines
Comments/Corrections

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