Document Detail

Differential ventilation in acute respiratory failure. Indications and outcome.
MedLine Citation:
PMID:  3890989     Owner:  NLM     Status:  MEDLINE    
Acute respiratory failure (ARF) is a life-threatening condition which frequently requires ventilatory support. Many patients die of hypoxaemia despite a high inspired oxygen concentration and application of general positive end-expiratory pressure (PEEP). Differential ventilation has been used in selected patients with unilateral lung disease or with large inequalities in pathology between the two lungs. An important contributor to the hypoxaemia is a vertical inequality in the ventilation-perfusion (V/Q) matching. This can be compensated for by placing the patient in the lateral position, ventilating each lung separately in proportion to its assumed blood flow, and applying PEEP selectively to the dependent lung to counteract airway closure and alveolar collapse and thus improve the gas distribution within that lung. This ventilatory regime should promote V/Q matching better than general PEEP, and will not impede cardiac output. Major improvement in gas exchange has been achieved in short-term experiments and in prolonged ventilator treatment of patients with ARF.
G Hedenstierna; S Baehrendtz; C Frostell; C Mebius
Related Documents :
9655699 - Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. dif...
343629 - Positive end-expiratory pressure. immediate haemodynamic effects during artificial vent...
21489059 - The relationship between self-efficacy and resting blood pressure in spousal alzheimer'...
19916859 - Central airway occlusion underestimates intrinsic positive end-expiratory pressure: a n...
9032519 - Heart-lung interactions: applications in the critically ill.
7005679 - Influence of positive end-expiratory pressure on left ventricular performance.
24578139 - Normal pressure hydrocephalus as a failure of icp homeostasis mechanism: the hidden rol...
2588209 - Decreased pulmonary distensibility in fibrosing alveolitis and its relation to decrease...
12793949 - Airway pressure release ventilation in pediatrics.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Bulletin européen de physiopathologie respiratoire     Volume:  21     ISSN:  0395-3890     ISO Abbreviation:  Bull Eur Physiopathol Respir     Publication Date:    1985 May-Jun
Date Detail:
Created Date:  1985-08-19     Completed Date:  1985-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605263     Medline TA:  Bull Eur Physiopathol Respir     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  281-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Anoxia / etiology
Middle Aged
Oxygen / blood
Positive-Pressure Respiration
Pulmonary Gas Exchange
Respiration, Artificial / methods*
Respiratory Insufficiency / complications,  physiopathology,  therapy*
Tidal Volume
Ventilation-Perfusion Ratio
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pulmonary diffusing capacity for carbon monoxide by rebreathing in mechanically ventilated patients.
Next Document:  Ventilatory support for pulmonary failure of the head trauma patient.