Document Detail


Differential vascular response to laser photothermolysis.
MedLine Citation:
PMID:  7963659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individual blood vessels in the chick choriallantoic membrane were selectively coagulated through photothermolysis, using pulsed laser irradiation at 585 nm. Pulse durations were chosen to be 0.45 ms and 10 ms, which correspond to the thermal relaxation times in blood vessels of 30 microns and 150 microns diameter, respectively. The short pulses, at a light fluence F = 3 Jcm-2, caused permanent occlusion of vessels of 40 microns diameter or less, whereas larger caliber vessels (60-120 microns) required F = 4-5 Jcm-2. The long-duration pulses, at F = 7 Jcm-2, caused coagulation of the larger diameter vessels; the small-caliber vessels and capillaries showed resistance to photothermolysis and required multiple exposures to achieve coagulation. The fluence versus diameter (F versus d) relationship for coagulation was calculated for the two pulse durations. The energy deposited in a cylindrical absorber of diameter d by an optical field, incident perpendicular to the vessel, was expressed analytically and compared with the energy required to coagulate a blood vessel of the same lumen dimeter. When thermal diffusion is incorporated into the model, our findings can be accounted for quantitatively. This information will be of use for improving the laser treatment of port wine stains and other vasculopathies. A surprising observation was that arterioles were damaged at lower incident energy densities than venules having the same lumen diameter, despite the fact that absorbance in oxygen-rich and oxygen-poor blood is the same at 585 nm.
Authors:
S Kimel; L O Svaasand; M Hammer-Wilson; M J Schell; T E Milner; J S Nelson; M W Berns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  103     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  693-700     Citation Subset:  IM    
Affiliation:
Beckman Laser Institute, University of California, Irvine 92715.
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MeSH Terms
Descriptor/Qualifier:
Allantois / blood supply
Animals
Blood Vessels / radiation effects*
Chick Embryo
Chorion / blood supply
Hot Temperature*
Laser Coagulation*
Models, Biological
Time Factors
Grant Support
ID/Acronym/Agency:
R01-AR42437-01A1/AR/NIAMS NIH HHS; R29-AR41638-01A1/AR/NIAMS NIH HHS; RR01192/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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