Document Detail


Differential utilization of long chain fatty acids during triacylglycerol depletion. I. Rat heart after ischemic perfusion.
MedLine Citation:
PMID:  3352474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rat hearts were perfused with Krebs-Henseleit buffer for 90 min according to the Langendorff procedure. Normoxic perfusion for 90 min resulted in minor changes in fatty acid composition and a decrease in residual heart triacylglycerol to 60% of preperfusion values. When the protocol included 30 min of slow perfusion-induced ischemia, the hearts were observed to be depleted of 89% of their initial triacylglycerol content. The triacylglycerol fatty acid composition (mg %) remained similar after compared to before perfusion except for a 121 mg % increase in stearic acid and a 225 mg % increase in arachidonic acid. The percentage composition of both fatty acids was significantly inversely correlated with the amount of triacylglycerol remaining in the heart after perfusion. Postperfusion, arachidonic acid and stearic acids were present at nearly 1:1 in the residual heart triacylglycerol, suggesting that a common mechanism may be involved in the selective retention of these fatty acids by the heart.
Authors:
S C Cunnane; M Karmazyn
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  23     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-05-06     Completed Date:  1988-05-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-4     Citation Subset:  IM    
Affiliation:
Efamol Research Institute, Kentville, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Disease / metabolism*
Fatty Acids / metabolism*
Male
Myocardium / metabolism*
Perfusion
Rats
Rats, Inbred Strains
Reference Values
Triglycerides / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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