Document Detail

Differential transplacental binding of valproic acid: influence of free fatty acids.
MedLine Citation:
PMID:  6430314     Owner:  NLM     Status:  MEDLINE    
The unbound fraction of valproic acid (VPA) was found to be significantly lower in cord serum (6.0 +/- 0.8%) than in maternal serum collected before oxytocin (12.2 +/- 2.7%) or after delivery (9.9 +/- 2.3%). The difference was probably due to the concentration of free fatty acids (acting as displacing agents) being higher in maternal serum. The transplacental binding gradient explains the clinical observation that total VPA levels at delivery are higher in the newborn than in the mother.
F Albani; R Riva; M Contin; A Baruzzi; M Altomare; G P Merlini; E Perucca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  17     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-09-13     Completed Date:  1984-09-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  759-62     Citation Subset:  IM    
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MeSH Terms
Fatty Acids, Nonesterified / blood*
Fetal Blood / metabolism*
Maternal-Fetal Exchange
Oxytocin / pharmacology
Protein Binding
Serum Albumin / metabolism
Valproic Acid / blood*
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Serum Albumin; 50-56-6/Oxytocin; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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