| Differential transplacental binding of valproic acid: influence of free fatty acids. | |
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MedLine Citation:
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PMID: 6430314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The unbound fraction of valproic acid (VPA) was found to be significantly lower in cord serum (6.0 +/- 0.8%) than in maternal serum collected before oxytocin (12.2 +/- 2.7%) or after delivery (9.9 +/- 2.3%). The difference was probably due to the concentration of free fatty acids (acting as displacing agents) being higher in maternal serum. The transplacental binding gradient explains the clinical observation that total VPA levels at delivery are higher in the newborn than in the mother. |
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Authors:
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F Albani; R Riva; M Contin; A Baruzzi; M Altomare; G P Merlini; E Perucca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 17 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-09-13 Completed Date: 1984-09-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 759-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dialysis Fatty Acids, Nonesterified / blood* Female Fetal Blood / metabolism* Humans Maternal-Fetal Exchange Oxytocin / pharmacology Pregnancy Protein Binding Serum Albumin / metabolism Valproic Acid / blood* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Serum Albumin; 50-56-6/Oxytocin; 99-66-1/Valproic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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