Document Detail

Differential transforming growth factor-beta secretion in adenocarcinoma and squamous cell carcinoma of the uterine cervix.
MedLine Citation:
PMID:  9062154     Owner:  NLM     Status:  MEDLINE    
Tumor cells from eight freshly isolated cervical cancers (i.e., four adenocarcinomas and four squamous carcinomas) were analyzed for their production of the immune-inhibitory cytokine transforming growth factor-beta (TGF-beta) in vitro. All fresh adenocarcinomas secreted significant levels of TGF-beta (mean 397, range between 207 and 782 pg/ml/10(5) cells/48 hr). In contrast, no detectable TGF-beta was present in the supernatants from the four fresh squamous carcinoma cultures (P < 0.001). These data suggest that major differences in the secretion of the immunoinhibitory cytokine TGF-beta exist between squamous cell carcinomas and adenocarcinomas of the uterine cervix. Furthermore, these findings suggest that at least some of the differences in the natural biologic behavior, as well as in the response to radiation treatment, between these two histologic types of cervical cancer could be related to differences in secretion of this immune-inhibitory cytokine.
A D Santin; P L Hermonat; J C Hiserodt; J Fruehauf; V Schranz; D Barclay; S Pecorelli; G P Parham
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gynecologic oncology     Volume:  64     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-14     Completed Date:  1997-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  477-80     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Arkansas, Little Rock 72205, USA.
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MeSH Terms
Adenocarcinoma / secretion*
Carcinoma, Squamous Cell / secretion*
Transforming Growth Factor beta / secretion*
Tumor Cells, Cultured
Uterine Neoplasms / secretion*
Reg. No./Substance:
0/Transforming Growth Factor beta

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